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PATZ1 Antibody

  • 中文名称：
    PATZ1兔多克隆抗体
  • 货号：
    CSB-PA593186
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA593186(PATZ1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9HBE1
  • 基因名：
    PATZ1
  • 别名：
    8430401L15Rik antibody; AI447519 antibody; and zinc finger-containing protein 1 antibody; AT hook- antibody; BTB POZ domain zinc finger transcription factor antibody; BTB/POZ domain zinc finger transcription factor antibody; dJ400N23 antibody; Mazr antibody; PATZ antibody; PATZ1 antibody; PATZ1_HUMAN antibody; POZ (BTB) and AT hook containing zinc finger 1 antibody; POZ , AT hook, and zinc finger containing protein 1 antibody; POZ- antibody; Protein kinase A RI subunit alpha associated protein antibody; Protein kinase A RI subunit alpha-associated protein antibody; RIAZ antibody; Transcription factor MAZR antibody; ZBTB19 antibody; Zfp278 antibody; Zinc finger and BTB domain containing protein 19 antibody; Zinc finger and BTB domain-containing protein 19 antibody; Zinc finger protein 278 antibody; Zinc finger protein 278, isoform CRA_d antibody; Zinc finger sarcoma gene protein antibody; ZNF278 antibody; ZSG antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human PATZ1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53. Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions.; (Microbial infection) Plays a positive role in viral cDNA synthesis.
  • 基因功能参考文献：
    1. The results of IHC and qPCR analyses showed that the expression of PATZ1 in cancerous tissue was significantly lower than that in non-cancerous tissues. Meanwhile, PATZ1 expression was significantly associated with tumor differentiation and LN metastasis. PMID: 29926841
    2. ZNF278 played a prominent role in the pathogenesis of colorectal cancer (CRC), and promoted CRC cell proliferation via the ERK/MAPK pathway, suggesting that it may act as a potential target in the diagnosis or treatment of CRC PMID: 29039562
    3. this study show that PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas PMID: 27494852
    4. Our results suggest that PATZ1 and PP4R2 provide negative feedback on IKK/NF-kappaB signaling to prevent cancer cells from over-stimulation from cellular stimuli PMID: 27391343
    5. The derived allele of rs174557, which is the common variant in most populations, diminishes binding of PATZ1, a transcription factor conferring allele-specific downregulation of FADS1. PMID: 27932482
    6. Loss of PATZ1 expression is associated with thyroid cancer progression. PMID: 25595894
    7. Results show that PATZ1 binds to p53 and inhibits p53-dependent transcription activation. PMID: 25755280
    8. these results propose that Patz1 is important for ESC pluripotency. PMID: 24380431
    9. The data support a PATZ1 tumour-suppressive function based on its ability to enhance p53-dependent transcription and apoptosis. PMID: 24336083
    10. PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging. PMID: 22052190
    11. these results showed a potentially novel mechanism of cAMP signaling mediated through the interaction of RIalpha with PATZ1. PMID: 20026299
    12. We report here the isolation and characterization of two novel nuclear BTB/POZ domain zinc finger isoformsthat are specifically expressed in early hippocampal neurons, cerebellar granule cells, and gliogenic progenitors as well as in differentiated glia PMID: 11744704
    13. MAZR and MITF synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF PMID: 11751862
    14. The results show that ZNF278 promotes cell growth, and its knockdown suppresses cell proliferation. ZNF278 could be a potential proto-oncogene in colorectal cancer. PMID: 18401526
    15. The short isoform of the Zinc finger Sarcoma Gene (ZSG) was isolated as a RNF4 interacting protein. PMID: 10949935

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  • 相关疾病：
    A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 13071

    OMIM: 605165

    KEGG: hsa:23598

    STRING: 9606.ENSP00000266269

    UniGene: Hs.731398