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PASK Antibody

  • 货号：
    CSB-PA822296LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA822296LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PASK Polyclonal antibody
  • Uniprot No.：
    Q96RG2
  • 基因名：
    PASK
  • 别名：
    DKFZP434O051 antibody; DKFZp686P2031 antibody; hPASK antibody; KIAA0135 antibody; MGC93882 antibody; mKIAA0135 antibody; PAS domain containing serine/threonine kinase antibody; PAS domain containing serine/threonine protein kinase antibody; PAS domain-containing serine/threonine-protein kinase antibody; PAS kinase antibody; PAS serine/threonine kinase antibody; PAS-kinase antibody; Pask antibody; PASK_HUMAN antibody; PASKIN antibody; STK 37 antibody; STK37 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PAS domain-containing serine/threonine-protein kinase protein (482-602AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PASK Antibody (CSB-PA822296LA01HU)，的标记方式是Non-conjugated。对于PASK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA822296LB01HU PASK Antibody, HRP conjugated ELISA
    FITC CSB-PA822296LC01HU PASK Antibody, FITC conjugated
    Biotin CSB-PA822296LD01HU PASK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
  • 基因功能参考文献：
    1. PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells. PMID: 23853095
    2. Mutations that affect PAS domain cause a severe protein trafficking defect and change the interactions with Kv11.1 channels. PMID: 23721480
    3. The role of PAS kinase in PASsing the glucose signal. PMID: 22219681
    4. Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) has a role in insulin hypersecretion PMID: 22065581
    5. PASK is involved in the regulation of glucagon secretion by glucose and may be a useful target for the treatment of type 2 diabetes. PMID: 21181396
    6. Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. PMID: 20943661
    7. molecular cloning, gene expression, and comparison with mouse protein PMID: 11688972
    8. Results suggest that elevated glucose concentrations rapidly increase Per-Arnt-Sim kinase activity in pancreatic islet beta cells, followed by up-regulation by glucose of preproinsulin and pancreatic duodenum homeobox 1 gene expression. PMID: 15148392
    9. identified the multifunctional eukaryotic translation elongation factor eEF1A1 as a novel interaction partner of PASKIN in the nuclei of testis germ cells and in the midpiece of sperm tails PMID: 17595531

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 组织特异性：
    Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).
  • 数据库链接：

    HGNC: 17270

    OMIM: 607505

    KEGG: hsa:23178

    STRING: 9606.ENSP00000234040

    UniGene: Hs.397891