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PARVB Antibody

  • 货号：
    CSB-PA017475GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9HBI1
  • 基因名：
  • 别名：
    PARVB antibody; CGI-56 antibody; Beta-parvin antibody; Affixin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PARVB
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
  • 基因功能参考文献：
    1. PARVB protein PMID: 25776890
    2. Protein expression of beta-Parvin increases with colorectal cancer progression. PMID: 26115385
    3. Taken together, our results indicate that 24-MCF treatment increases parvin-beta expression, which may inhibit ILK downstream signaling. PMID: 26549231
    4. study found polymorphisms of rs5764455 and rs6006473 in PARVB gene in the Han Chinese population, and these polymorphisms were associated with the occurrence and progression of NAFLD. PMID: 26343796
    5. Our results suggested that variations, including insertion/deletions, in PARVB, as well as those in PNPLA3, are important in the progression of NAFLD. PMID: 24621583
    6. PARVB overexpression is a candidate biomarker for endophytic tumours and metastasis. PMID: 25422907
    7. PARVB plays a potential role in the pathogenesis of coronary restenosis. PMID: 23950981
    8. alpha-parvin, beta-parvin and migfilin were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively. PMID: 23099104
    9. proper localization of beta-parvin to focal adhesions requires both the paxillin and integrin-linked kinase binding sites and that paxillin is important for early targeting of beta-parvin. PMID: 22869380
    10. Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication. PMID: 20345489
    11. downexpression of ParvB level in urothelial cell carcinoma of the upper urinary tract (UUT-UC) correlated with tumour stage, and was an independent unfavourable prognostic factor for disease-specific survival of patients with UUT-UC PMID: 20736946
    12. Data from functional molecular imaging demonstrated that beta-parvin plays a regulatory role in the ILK-mediated Akt (also called protein kinase B) signaling cascades, suggesting that beta-parvin might be a crucial modulator of cell survival. PMID: 20164304
    13. Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization. PMID: 11722847
    14. the ILK-affixin complex has a role in integrin-cytoskeleton linkage during platelet aggregation [affixin] PMID: 12372433
    15. affixin provide a novel signalling pathway that links integrin signalling to Cdc42/Rac1 activation. PMID: 15005707
    16. ILK-affixin complex serves as an integrin-anchoring site for alpha-actinin and thereby mediates integrin signaling to alpha-actinin, which has been shown to play a critical role in actin polymerization at focal adhesions. PMID: 15159419
    17. alpha- and beta-parvins play distinct roles in Rac activation or lamellipodium formation and protection of cells from apoptosis. PMID: 15284246
    18. loss of ParvB expression is a novel mechanism for upregulating ILK activity in tumors PMID: 15467740
    19. Data show that affixin is a dysferlin binding protein that colocalizes with dysferlin at the sarcolemma of normal skeletal muscle. PMID: 15835269
    20. Parvin-beta might influence breast cancer progression PMID: 17998334
    21. results suggest that affixin is involved in reorganization of subsarcolemmal cytoskeletal actin by activation of Rac1 through alpha and betaPIXs in skeletal muscle PMID: 18325335

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
  • 蛋白家族：
    Parvin family
  • 组织特异性：
    Expressed predominantly in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 14653

    OMIM: 608121

    KEGG: hsa:29780

    STRING: 9606.ENSP00000384515

    UniGene: Hs.475074