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PAPSS1 Antibody

  • 货号：
    CSB-PA203103
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA203103(PAPSS1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA203103(PAPSS1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O43252
  • 基因名：
    PAPSS1
  • 别名：
    3 prime phosphoadenosine 5 prime phosphosulfate synthase 1 antibody; 3' phosphoadenosine 5' phosphosulfate synthase 1 antibody; 3''-phosphoadenosine-5''-phosphosulfate synthase antibody; Adenosine-5''-phosphosulfate 3''-phosphotransferase antibody; Adenylyl-sulfate kinase antibody; Adenylylsulfate 3''-phosphotransferase antibody; APS kinase antibody; ATP-sulfurylase antibody; ATPSK 1 antibody; ATPSK1 antibody; ATPSK2 antibody; Bifunctional 3' phosphoadenosine 5' phosphosulfate synthetase 1 antibody; PAPS synthase 1 antibody; PAPS synthetase 1 antibody; PAPS1_HUMAN antibody; PAPSS 1 antibody; PAPSS antibody; PAPSS1 antibody; SAT antibody; SK 1 antibody; SK1 antibody; SK2 antibody; Sulfate adenylate transferase antibody; Sulfurylase kinase 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human PAPSS1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells.
  • 基因功能参考文献：
    1. These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Developing strategies to target PAPSS1 activity in conjunction with platinum-based chemotherapy may offer an approach to improving treatment outcomes PMID: 28790117
    2. we found that ectopic expression of oncogenic KRas and HRas in cells resulted in elevated CIB1 expression. We previously described the Ca(2+)-myristoyl switch function of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1), a location where SK1 is known to elicit oncogenic signalling. PMID: 27941888
    3. leptin signalling links a novel SFK/ERK1/2-mediated pathway and SK1 expression. PMID: 25482303
    4. SK1 positivity and high expression were significantly associated with cancer and a shorter 5-year and overall survival. PMID: 24587339
    5. study showed expression patterns of SULT1E1 and PAPSS in breast and endometrial tissues; the estrogen sulfation enzymes were comparatively higher in the tumorous tissues than adjacent normal tissues; overexpression of SULT1E1 and PAPSS1 retarded MCF-7 cells growth in vivo and in vitro by arresting cell cycles and inducing apoptosis PMID: 22380844
    6. SK1 plays an essential role in regulating in vitro paracrine angiogenesis and lymphangiogenesis. PMID: 20335228
    7. characterization and expression of bifunctional isoforms PMID: 11931637
    8. review of PAPSS biochemistry, molecular biology and genetics PMID: 12716056
    9. x-ray crystallographic analysis of 3'-phosphoadenosine-5'-phosphosulfate synthetase 1 PMID: 14747722
    10. The kinetic characteristics of the individual sulfurylase and kinase activities of PAPSS isoform 1, the predominant form in human brain, are described. PMID: 15065880
    11. Results describe the crystal structure of human PAPSS1 at 1.8 angstroms resolution. PMID: 15755455
    12. ATP-sulfurylase domain of PAPS synthetase influences these elements in adenylylsulfate kinase, which may be a mechanism between both domains the this bifunctional enzyme PMID: 17540769
    13. a role for PAPSS1 in the cellular sulfonation pathway requirement at a stage during or shortly after MLV provirus establishment, and subsequent influence on gene expression from the viral long terminal repeat promoter PMID: 19008949
    14. PAPSS1 maps to chromosome 4q25 and may havea role in hepatocellular carcinoma PMID: 19337310

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  • 蛋白家族：
    APS kinase family; Sulfate adenylyltransferase family
  • 组织特异性：
    Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage.
  • 数据库链接：

    HGNC: 8603

    OMIM: 603262

    KEGG: hsa:9061

    STRING: 9606.ENSP00000265174

    UniGene: Hs.368610