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PAOX Antibody

  • 中文名称：
    PAOX兔多克隆抗体
  • 货号：
    CSB-PA004746
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of rat stomach K562 cells using PAOX Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q6QHF9
  • 基因名：
    PAOX
  • 别名：
    PAOX antibody; PAO antibody; UNQ1923/PRO4398Peroxisomal N(1)-acetyl-spermine/spermidine oxidase antibody; EC 1.5.3.13 antibody; Polyamine oxidase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PAOX.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
  • 基因功能参考文献：
    1. copy number gain in the polyamine oxidase (PAOX) gene locus was accompanied by a coordinated transcriptional up-regulation in Primary myelofibrosis patients PMID: 26547506
    2. PAO activity in children with type 1 diabetes mellitus was very high; higher blood HbA(1C) and MDA levels confirm the presence of oxidant stress demonstrate that PAO activity may participate in these circumstances PMID: 20405312
    3. polyamine oxidase degrades alpha-methylpolyamines in a stereospecific manner PMID: 16354669
  • 亚细胞定位：
    Peroxisome. Cytoplasm.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 组织特异性：
    Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.
  • 数据库链接：

    HGNC: 20837

    OMIM: 615853

    KEGG: hsa:196743

    STRING: 9606.ENSP00000278060

    UniGene: Hs.501578