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PANX3 Antibody

  • 货号：
    CSB-PA839402LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate
      All lanes: PANX3 antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA839402LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PANX3 Polyclonal antibody
  • Uniprot No.：
    Q96QZ0
  • 基因名：
    PANX3
  • 别名：
    PANX3; Pannexin-3
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pannexin-3 protein (135-215AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PANX3 Antibody (CSB-PA839402LA01HU)，的标记方式是Non-conjugated。对于PANX3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA839402LB01HU PANX3 Antibody, HRP conjugated ELISA
    FITC CSB-PA839402LC01HU PANX3 Antibody, FITC conjugated
    Biotin CSB-PA839402LD01HU PANX3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Structural component of the gap junctions and the hemichannels.
  • 基因功能参考文献：
    1. Panx3 was upregulated during osteogenic differentiation in a time-dependent manner. Panx3 overexpression promoted osteogenic differentiation of human dental pulp-derived mesenchymal stromal cells, whereas depletion of Panx3 resulted in a decline of differentiation. PMID: 29241211
    2. Panx3 channels regulate the proliferation, differentiation, and fusion of skeletal muscle myoblasts. (Review) PMID: 27518505
    3. Panx3 has a defensive role in dental pulp inflammation. PMID: 27679980
    4. Case Report: osteosarcomatous transformation of axillary sweat gland neoplasm with high PANX3 expression. PMID: 27391460
    5. Panx3 hemichannel is expressed in human odontoblast-like cells and mediates ATP release into the extracellular space. PMID: 26263540
    6. Panx1 and Panx3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation. PMID: 25239622
    7. The 70 kDa immunoreactive species of Panx3 highly regulated during keratinocyte differentiation was shown to most likely correspond to another Panx3 isoform. PMID: 22947051
    8. Panx3 functions to switch the chondrocyte cell fate from proliferation to differentiation by regulating the intracellular ATP/cAMP levels PMID: 20404334
    9. although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules PMID: 20086016
    10. These studies show that Panx1 and Panx3 have many characteristics that are distinct from Cx43 and that these proteins probably play an important biological role as single membrane channels. PMID: 17925379

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Pannexin family
  • 数据库链接：

    HGNC: 20573

    OMIM: 608422

    KEGG: hsa:116337

    UniGene: Hs.99235