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PANK1 Antibody

  • 货号：
    CSB-PA017421LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017421LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA017421LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PANK1 Polyclonal antibody
  • Uniprot No.：
    Q8TE04
  • 基因名：
    PANK1
  • 别名：
    coaA antibody; hPanK antibody; hPanK1 antibody; PANK antibody; PANK1 antibody; PANK1_HUMAN antibody; PANK1a antibody; PANK1b antibody; PanK1beta antibody; Pantothenate kinase 1 antibody; Pantothenate kinase antibody; Pantothenic acid kinase 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pantothenate kinase 1 protein (462-582AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PANK1 Antibody (CSB-PA017421LA01HU)，的标记方式是Non-conjugated。对于PANK1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017421LB01HU PANK1 Antibody, HRP conjugated ELISA
    FITC CSB-PA017421LC01HU PANK1 Antibody, FITC conjugated
    Biotin CSB-PA017421LD01HU PANK1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
  • 基因功能参考文献：
    1. p53 plays an important role in regulating energy homeostasis through transcriptional control of PANK1. PMID: 23343762
    2. PANK deficiency leads to abnormalities in F-actin organization. PMID: 22912811
    3. molecular cloning and characterization of a new human PanK gene PMID: 11809413
    4. alternative splicing product PMID: 12379284
    5. PPARalpha transcription factor as a major factor governing hepatic CoA levels by specific modulation of PANK1alpha gene expression PMID: 14523052
    6. analysis of the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA and the the structural effects of the PanK2 mutations that have been implicated in neurodegeneration PMID: 17631502

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  • 亚细胞定位：
    Cytoplasm.; [Isoform 1]: Nucleus. Nucleus, nucleolus.; [Isoform 2]: Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome.
  • 蛋白家族：
    Type II pantothenate kinase family
  • 组织特异性：
    [Isoform 1]: Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis.; [Isoform 2]: Detected at much lower levels in kidney, liver, brain and testis and not detected in heart or skeletal muscle.
  • 数据库链接：

    HGNC: 8598

    OMIM: 606160

    KEGG: hsa:53354

    STRING: 9606.ENSP00000302108

    UniGene: Hs.163555