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PAIP1 Antibody

  • 货号：
    CSB-PA017400GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H074
  • 基因名：
    PAIP1
  • 别名：
    MGC12360 antibody; OTTHUMP00000221601 antibody; OTTMUSP00000026880 antibody; PABC1 interacting protein 1 antibody; PABP interacting protein 1 antibody; PABP-interacting protein 1 antibody; PAIP 1 antibody; PAIP-1 antibody; Paip1 antibody; PAIP1_HUMAN antibody; Poly(A) binding protein interacting protein 1 antibody; Poly(A)-binding protein-interacting protein 1 antibody; Polyadenylate binding protein interacting protein 1 antibody; Polyadenylate-binding protein-interacting protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PAIP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.; (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis.
  • 基因功能参考文献：
    1. Results showed that mRNA and protein expression of PAIP1, a miRNA-340 target gene, were down-regulated in women with gestational diabetes. PMID: 29358694
    2. Data provide evidence that the stability of Paip1 can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation. PMID: 25266661
    3. The Paip1-eIF3 interaction is impaired by the mTORC1 inhibitors. PMID: 24396066
    4. the crystal structure of the middle domain of Paip1 isoform 2 (Paip1M) as determined by single-wavelength anomalous dispersion phasing is reported. PMID: 21539810
    5. Paip1 is translational activator in 5' cap-dependent translation by interacting with PABP & initiation factors eIF4A & eIF3. Crystallization & preliminary diffraction analysis of middle domain of Paip1 gives crystals that diffract to resolution of 2.2 A. PMID: 19851022
    6. Paip1 interacts with poly(A) binding protein through two independent binding motifs. PMID: 11997512
    7. eIF3-Paip1 stabilizes the interaction between PABP and eIF4G, which brings about the circularization of the mRNA. PMID: 18725400

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  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    HGNC: 16945

    OMIM: 605184

    KEGG: hsa:10605

    STRING: 9606.ENSP00000302768

    UniGene: Hs.482038