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PAFAH1B2 Antibody

  • 货号：
    CSB-PA017384GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P68402
  • 基因名：
    PAFAH1B2
  • 别名：
    Intracellular platelet activating factor acetylhydrolase alpha 2 subunit antibody; PA1B2_HUMAN antibody; PAF acetylhydrolase 30 kDa subunit antibody; PAF AH 30 kDa subunit antibody; PAF AH beta subunit antibody; PAF AH subunit beta antibody; PAF-AH 30 kDa subunit antibody; PAF-AH subunit beta antibody; PAFAH 30 kDa subunit antibody; PAFAH beta subunit antibody; PAFAH subunit beta antibody; Pafah1b2 antibody; PAFAH1B2 protein antibody; PAFAHB antibody; Platelet activating factor acetylhydrolase 1b catalytic subunit 2 antibody; Platelet activating factor acetylhydrolase IB beta subunit antibody; Platelet activating factor acetylhydrolase IB subunit beta antibody; Platelet activating factor acetylhydrolase isoform Ib beta subunit antibody; Platelet activating factor acetylhydrolase isoform Ib subunit 2 antibody; Platelet-activating factor acetylhydrolase IB subunit beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PAFAH1B2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis.
  • 基因功能参考文献：
    1. PAF is demonstrated to be the key indicator in the lipid metabolism of polypoidal choroidal vasculopathy patients in this study. PMID: 27910906
    2. PAFAH1B2 and 1B3 are important in maintaining cancer pathogenicity across a wide spectrum of cancer types. PMID: 25945974
    3. The R92H and I198T polymorphisms are highly related to the plasma PAF-AH levels and the risk of coronary heart disease, especially among patients with blood stasis syndrome. PMID: 25034894
    4. aspirin is hydrolyzed in plasma by two enzymes, BChE and a new extracellular form of platelet-activating factor acetylhydrolase, PAFAH1b2. PMID: 23508960
    5. Knockdown of PAFAH1B2 strongly reduced Abeta secretion from human cells, and this effect was confirmed in primary cells derived from PAFAH1B2 knock-out mice PMID: 23238734
    6. Plasma PAF-AH can hydrolyze oxidized phospholipids, and may attenuate the spreading of lipid peroxidation and participate in defense mechanisms against vasospasm after aneurysmal subarachnoid hemorrhage. PMID: 21866060
    7. intracellular type I PAF acetylhydrolase (PAFAH1B2 and PAFAH1B3) is the major aspirin hydrolase of human blood PMID: 21844189
    8. PAFAH1B2 is not the gene responsible for the linkage evidence on chromosome 11q23 in protein C deficiency. PMID: 17849047
    9. splice variants of the Pafah1b2 gene transcript retain exons 1-5 and replace exon 6 with alternative exons derived from genomic sequence 3' to exon 6. Splice variants encode two proteins with different novel carboxy termini PMID: 18155631

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    'GDSL' lipolytic enzyme family, Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 8575

    OMIM: 602508

    KEGG: hsa:5049

    STRING: 9606.ENSP00000435289

    UniGene: Hs.728488