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PADI3 Antibody

  • 货号：
    CSB-PA891552LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA891552LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA891552LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PADI3 Polyclonal antibody
  • Uniprot No.：
    Q9ULW8
  • 基因名：
    PADI3
  • 别名：
    PADI3 antibody; PADI3_HUMAN antibody; PDI3 antibody; Peptidyl arginine deiminase; type III antibody; Peptidylarginine deiminase III antibody; Protein arginine deiminase type 3 antibody; Protein arginine deiminase type III antibody; Protein-arginine deiminase type III antibody; Protein-arginine deiminase type-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein-arginine deiminase type-3 protein (1-664AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PADI3 Antibody (CSB-PA891552LA01HU)，的标记方式是Non-conjugated。对于PADI3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA891552LB01HU PADI3 Antibody, HRP conjugated ELISA
    FITC CSB-PA891552LC01HU PADI3 Antibody, FITC conjugated
    Biotin CSB-PA891552LD01HU PADI3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the deimination of arginine residues of proteins.
  • 基因功能参考文献：
    1. The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation. PMID: 27866708
    2. Crystals of PAD3 obtained using polyethylene glycol 400 as a precipitant diffracted to 2.95 A resolution using synchrotron radiation PMID: 22684066
    3. PAD3 is co-located with filaggrin within the filamentous matrix of the deeper corneocytes where the protein is deiminated. PMID: 16091842
    4. PADI3 expression is driven by Sp1/Sp3 and NF-Y binding to the promoter region PMID: 16671893
    5. cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3) PMID: 18083705
    6. Peptidylarginine deiminase Intergenic Enhancer is a strong enhancer of the PADI3 promoter in Ca2+-differentiated epidermal keratinocytes, and requires bound PMID: 18923650
    7. These results reveal the molecular bases of the expression specificity of PADI1 and PADI3 during keratinocyte differentiation through a long-range enhancer and support a model of PADI gene regulation depending on c-Jun-JunD competition. PMID: 18952102

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  • 相关疾病：
    Uncombable hair syndrome 1 (UHS1)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein arginine deiminase family
  • 组织特异性：
    Hair follicles, and epidermis at very low levels.
  • 数据库链接：

    HGNC: 18337

    OMIM: 191480

    KEGG: hsa:51702

    STRING: 9606.ENSP00000364609

    UniGene: Hs.149195