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PACSIN1 Antibody

  • 货号：
    CSB-PA017373GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BY11
  • 基因名：
    PACSIN1
  • 别名：
    A830061D09Rik antibody; Dynamin PRD-interacting protein antibody; Dynamin proline-rich domain-interacting protein antibody; H74 antibody; KIAA1379 antibody; MGC114042 antibody; MGC56324 antibody; mKIAA1379 antibody; OTTHUMP00000016231 antibody; PACN1_HUMAN antibody; Pacsin1 antibody; PASCIN antibody; Protein kinase C and casein kinase substrate in neurons 1 antibody; Protein kinase C and casein kinase substrate in neurons protein 1 antibody; SDPI antibody; Synaptic, dynamin-associated protein I antibody; Syndapin 1 antibody; Syndapin antibody; Syndapin-I antibody; zgc:114042 antibody; zgc:56324 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PACSIN1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. Binds to membranes via its F-BAR domain and mediates membrane tubulation.
  • 基因功能参考文献：
    1. Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7. PMID: 24205826
    2. Data indicate that the structural capacity of N17 to fold back toward distal regions within huntingtin requires an interacting protein, protein kinase C and casein kinase 2 substrate in neurons 1 (PACSIN1). PMID: 23898200
    3. Pacsin-1 plays a versatile role in sculpting cellular membranes that is likely dependent both on protein structure and membrane properties. PMID: 23236520
    4. PACSIN1 represents a pDC-specific adaptor molecule that plays an important role in the TLR7/9-mediated type I IFN responses by pDCs in vitro and in vivo. PMID: 22488361
    5. Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation PMID: 22355135
    6. PACSIN 1 (1-344) was crystallized & diffracted to resolution of 3.0 A. The crystal belonged to space group C2, with unit-cell parameters a=158.65, b=87.38, c=91.76 A, alpha=90.00, beta=113.61, gamma=90.00 degrees. There are 2 molecules in asymmetric unit. PMID: 20057076

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  • 亚细胞定位：
    Cytoplasm. Cell projection. Cell junction, synapse, synaptosome. Cell projection, ruffle membrane. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    PACSIN family
  • 组织特异性：
    Highly expressed in brain and, at much lower levels, in heart and pancreas.
  • 数据库链接：

    HGNC: 8570

    OMIM: 606512

    KEGG: hsa:29993

    STRING: 9606.ENSP00000244458

    UniGene: Hs.520087