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P2RY11 Antibody

  • 货号：
    CSB-PA003635
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using P2Y11 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96G91
  • 基因名：
  • 别名：
    P2RY11; P2Y purinoceptor 11; P2Y11
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human P2Y11.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.
  • 基因功能参考文献：
    1. these results show hepatocellular carcinoma-specific expression of the P2Y11 receptor and its critical role in mediating ATP-inducing Ca2+ signalling and regulating cancer cell migration PMID: 28418839
    2. Decreased P2Y11 signaling plays an important role in the development of narcolepsy with cataplexy. PMID: 28460015
    3. Hypoxia/reoxygenation inhibits P2y11 receptor expression and its immunosuppressive activity in human dendritic cells. PMID: 26078273
    4. Suggest role for LXA4 in stimulating apical ATP secretion via pannexin-1 channels and P2RY11 purinoreceptors activation leading to an airway surface liquid layer height increase and epithelial repair. PMID: 24588705
    5. vesicular exocytosis of ATP and autocrine, positive feedback through P2Y11 receptors is required for the effective activation of macrophages PMID: 23577075
    6. P2Y11 receptor mediates interferon gamma-induced IL-6 production in HaCaT cells, suggesting the importance of purinergic signaling in interferon-gamma induced skin inflammatory conditions PMID: 23461851
    7. P2Y11 receptors are abundantly and diffusely expressed intracellularly in skeletal muscle fibers. PMID: 22052557
    8. The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population. PMID: 22177342
    9. Extracellular NAD stimulates mesenchymal stem cell functions through activation of P2Y11 receptor. PMID: 20964598
    10. Common variants in P2RY11 are associated with narcolepsy. PMID: 21170044
    11. Inhibition of Natural killer cell response to CX3CL1 is mediated by the P2Y11 receptor. PMID: 20668227
    12. beta-NAD(e)+ is an agonist of the P2Y(11) purinoceptor and P2Y(11) is the endogenous receptor in granulocytes mediating the sustained [Ca2+]i increase responsible for their functional activatio PMID: 16926152
    13. We propose that residues Arg106, Arg268, Arg307 and Glu186 are involved in ionic interactions with the phosphate moiety of ATP. Arg307 is possibly also H-bonded to N6 of ATP via the backbone carbonyl. PMID: 17338680
    14. In human granulocytes, endogenous P2Y(11) proved to be responsible for NAADP+-induced cell activation, unveiling a role of NAADP+ as a pro-inflammatory cytokine. PMID: 17707504
    15. The P2 receptor mediating the antiapoptotic actions of ATP was identified using a combination of more selective ATP analogs, receptor expression studies, and study of downstream signaling pathways. PMID: 18056402
    16. present data clearly show that P2Y purinoceptor 11 and P2Y purinoceptor 12 are expressed in human pancreatic islets PMID: 18726826

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Highest expression in liver and spleen.
  • 数据库链接：

    HGNC: 8540

    OMIM: 602697

    KEGG: hsa:5032

    STRING: 9606.ENSP00000323872

    UniGene: Hs.14468