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P2RX5 Antibody

  • 货号：
    CSB-PA017323GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q93086
  • 基因名：
  • 别名：
    ATP receptor antibody; ATP receptor subunit antibody; Ionotropic ATP receptor P2X5 antibody; LRH 1 antibody; LRH1 antibody; Lymphoid restricted histocompatibility antigen 1 antibody; MGC47755 antibody; P2rx5 antibody; P2RX5_HUMAN antibody; P2X purinoceptor 5 antibody; P2X5 antibody; P2X5R antibody; Purinergic receptor antibody; Purinergic receptor P2X ligand gated ion channel 5 antibody; Purinergic receptor P2X5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human P2RX5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for ATP that acts as a ligand-gated ion channel.
  • 基因功能参考文献：
    1. The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes. PMID: 25080478
    2. These data indicate a functional role of the human P2RX5 splice variant in T cell activation and immunoregulation. PMID: 25181038
    3. These findings provide a rationale for use of LRH-1 as immunotherapeutic target antigen to treat residual or persisting myeloid malignancies after allogeneic stem cell transplantation PMID: 19074734
    4. Purinergic receptor P2X5 binds to adenosine triphosphate (ATP) to form a molecular complex with ASIC3 (acid-sensing ion channel number 3) to detect muscle ischemia. PMID: 21092862
    5. findings indicate that most humans express only a nonfunctional isoform of P2X5, which is in stark contrast to what is seen in other vertebrate species in which P2X5 has been studied, from which only the full-length isoform is known PMID: 20223879
    6. Different purinergic receptors have different functional roles in human epidermis with P2Y1 and P2Y2 receptors controlling proliferation, while P2X5 and P2X7 receptors control early differentiation, terminal differentiation and death of keratinocytes. PMID: 12787128
    7. Non-melanoma skin cancers express functional purinergic receptors and that P2X7 receptor agonists significantly reduce cell numbers in vitro. PMID: 12880424
    8. a P2X5 frameshift mutation has a role in response to treatment of chronic myeloid leukemia PMID: 16322791
    9. Increased keratinocyte P2X(5) receptor activity may, in part, be accountable for epidermal thinning in chronic venous insufficiency. PMID: 16967306
    10. analysis of topology, helix-helix interactions, and oligomerization of P2X5 subunits PMID: 17001079
    11. LRH-1 is aberrantly expressed on solid tumor cells PMID: 18719914

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    P2X receptor family
  • 组织特异性：
    Expressed at high levels in brain and immune system.
  • 数据库链接：

    HGNC: 8536

    OMIM: 602836

    KEGG: hsa:5026

    STRING: 9606.ENSP00000225328

    UniGene: Hs.731607