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P2RX3 Antibody

  • 货号：
    CSB-PA056352
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA056352(P2RX3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA056352(P2RX3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human bladder tissue, Human bladder transitional cell carcinoma tissue, Primary antibody: CSB-PA056352(P2RX3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P56373
  • 基因名：
  • 别名：
    ATP receptor antibody; MGC129956 antibody; P2rx3 antibody; P2RX3_HUMAN antibody; P2X purinoceptor 3 antibody; P2X receptor subunit 3 antibody; P2X3 antibody; Purinergic receptor antibody; Purinergic receptor P2X ligand gated ion channel 3 antibody; Purinergic receptor P2X3 antibody; Purinoceptor P2X3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human P2RX3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for ATP that acts as a ligand-gated cation channel. Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception.
  • 基因功能参考文献：
    1. Druggable negative allosteric site of P2X3 receptors. PMID: 29674445
    2. conclude that the inter-subunit salt bridge between E112 and R198 of the head and dorsal fin domains, respectively, serves to control the mobility of these domains during agonist-activation of the hP2X3R PMID: 26825305
    3. P2X3 expressions in endometriosis endometrium and endometriotic lesions were significantly higher as compared with control endometrium, and positively correlated with pain. PMID: 28898282
    4. P2X3 receptor expression was up-regulated in neurons from patients with temporal lobe epilepsy. PMID: 26738991
    5. X-ray crystal structures of the human P2X3 receptor in apo/resting, agonist-bound/open-pore, agonist-bound/closed-pore/desensitized and antagonist-bound/closed states PMID: 27626375
    6. there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients. PMID: 27312548
    7. Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor hP2X2/3 channel. PMID: 27129281
    8. Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC) therapy. PMID: 26517690
    9. Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 and P2X3 subunits PMID: 26184350
    10. Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection. PMID: 26241848
    11. The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2, P2X3 and P2X7 receptors in the different histological layers of the human urinary bladder. PMID: 26253104
    12. sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns PMID: 24868547
    13. esophagitis increases mRNA expressions of P2X3 and P2X7 receptors accompanied by up-regulation of TRPV1 and neurotrophic factors (NGF and GDNF). PMID: 25336328
    14. Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening PMID: 24989924
    15. TRPV1-, TRPV2-, P2X3-, and parvalbumin-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve PMID: 24764033
    16. Data indicate that Markov models are suitable to simulate agonist antagonist interactions at fast desensitizing receptors such as the P2X3R. PMID: 24223907
    17. ATP-gated P2X3 channels in enterochromaffin cells are downregulated in ulcerative colitis. PMID: 23917247
    18. An early and broad expression of P2X3 receptors was found in prenatal dorsal root ganglion neurons. PMID: 22052556
    19. HEK 293 cells are not permissive for stable P2X3 expression afer a significant time-dependent cell loss; often used in a recmbinant expression system, HEK cells represent a limiting permissive environment for P2X3 receptors. PMID: 22160848
    20. Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article] PMID: 22963434
    21. The effects of single alanine substitutions of amino acid residues in the supposed ATP binding site of the human P2X3 receptor on the agonistic effect of nucleotide analogs. PMID: 22498660
    22. one subunit of P2X2 and two subunits of P2X3 form P2X2/3 heteromeric receptors, whereas two subunits of P2X2 and one subunit of P2X6 constitute P2X2/6 receptors PMID: 22378790
    23. Amino acid residues constituting the agonist binding site of the human P2X3 receptor. PMID: 21098022
    24. P2X3 positive fibres in the trigeminal sensory system were significantly increased in burning mouth syndrome patients compared with controls. PMID: 20418063
    25. The present data indicate a novel target, P2X3 receptors, to express the action of Cdk5 on membrane proteins involved in pain perception. PMID: 19960242
    26. Released ATP activates P2X(3) receptors in the beta-cell plasma membrane, resulting in increased [Ca(2+)](i) and enhanced insulin secretion. PMID: 20308565
    27. P2X(1) receptors showed an anti-inflammatory effect reducing NF-kappaB activation and TNF-alpha release whilst P2X(3) receptors mediated opposite response. PMID: 20110693
    28. Review. Activation of P2X(3)-containing channels is an important mediator of persistent nociceptive signalling. The data also indicate potential discrete roles for homomeric P2X(3) & heteromeric P2X(2/3) receptor activation in acute & chronic pain. PMID: 12885270
    29. in fibers of human tooth pulp ... may play a role in perception of dental pain PMID: 14520770
    30. Effect of acute hypoxia on cloned homo- and heteromeric P2X3 receptors expressed in human embryonic kidney 293 cells. PMID: 15331767
    31. negative residues in the P2X3 ATP receptor ectodomain are structural determinants for desensitization and the Ca2+-sensing modulatory sites PMID: 15475563
    32. These data indicate that PKC activation can enhance both the Ca(2+) signal as well as the cation current through P2X(3)R, however it appears that the regulation is unlikely to be a result of direct phosphorylation of the receptor. PMID: 17052768
    33. genetic and pharmacological approaches have provided converging evidence that activation of P2X3-containing channels is an important mediator of acute and persistent nociceptive signaling--review PMID: 18600577
    34. Sodium Ferrulate may inhibit the initiation of pain and primary afferent sensitization mediated by P2X(3) receptor during chronic constriction injury. PMID: 18805451
    35. These cells expressed P2X3 receptors. Suburothelial myofibroblasts may be intermediate in processing adenosine triphosphate-mediated sensory activation PMID: 19456993

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    P2X receptor family
  • 数据库链接：

    HGNC: 8534

    OMIM: 600843

    KEGG: hsa:5024

    STRING: 9606.ENSP00000263314

    UniGene: Hs.146738