Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. OVOL2 Antibody

OVOL2 Antibody

  • 货号：
    CSB-PA887110HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA887110HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) OVOL2 Polyclonal antibody
  • Uniprot No.：
    Q9BRP0
  • 基因名：
    OVOL2
  • 别名：
    bA504H3.3 antibody; EUROIMAGE566589 antibody; hOvo 2 antibody; hOvo2 antibody; Ovo like 2 (Drosophila) antibody; Ovo like 2 antibody; ovo-like zinc finger 2 antibody; OVOL 2 antibody; OVOL2 antibody; OVOL2_HUMAN antibody; Transcription factor Ovo like 2 antibody; Transcription factor Ovo-like 2 antibody; Zinc finger protein 339 antibody; ZNF 339 antibody; ZNF339 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transcription factor Ovo-like 2 protein (19-114AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，OVOL2 Antibody (CSB-PA887110HA01HU)，的标记方式是Non-conjugated。对于OVOL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA887110HB01HU OVOL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA887110HC01HU OVOL2 Antibody, FITC conjugated
    Biotin CSB-PA887110HD01HU OVOL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos.
  • 基因功能参考文献：
    1. Taken together, this study suggests that the OVOL1-OVOL2 axis is a key modulator of c-Myc expression in the shift from in situ epidermal malignancy (Bowen's disease) to invasive squamous cell carcinoma. PMID: 28339425
    2. OVOL2 antagonizes TGF-beta signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis. PMID: 28455959
    3. the OVOL2 promoter variant c.-307T>C was herein identified in the original family that established the posterior polymorphous corneal dystrophy 1 locus. PMID: 28046031
    4. OVOL2 maintains the transcriptional program of human corneal epithelium cells. PMID: 27134177
    5. hOvol2 expression was restricted to the XY body of spermatocytes at the pachytene stage. This study demonstrates that hOvol2 is expressed in germ cells and may be involved in spermatogenesis. PMID: 27136193
    6. Ovol2 can suppress migration and invasion ability of A549 cells, and prevent EMT by inhibition of Twist1 transcription directly. PMID: 27884772
    7. congenital hereditary endothelial dystrophy 1 (CHED1) and CHED2 loci on chromosome 20 and the collagen, type VIII, alpha-2 (COL8A2) gene were excluded by linkage and haplotype analyses. PMID: 12654361
    8. We report the absence of a presumed pathogenic coding region mutation in the common PPCD1 support interval. PMID: 19574904
    9. that the OVOL1-OVOL2 axis may actively contribute to cell differentiation and proliferation in the hair bulb PMID: 26873447
    10. OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-beta-catenin complex. PMID: 26619963
    11. data demonstrate that all four mutated OVOL2 promoters exhibited more transcriptional activity than the corresponding wild-type promoter PMID: 26749309
    12. Molecular phylogeny of OVOL1, OVOL2 and OVOL3 genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions in humans and other species PMID: 22737237
    13. Ovol2 directly represses two critical downstream targets, c-Myc and Notch1, thereby suppressing keratinocyte transient proliferation and terminal differentiation, respectively PMID: 19700410

    显示更多

    收起更多

  • 相关疾病：
    Corneal dystrophy, posterior polymorphous, 1 (PPCD1)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in testis, ovary, heart and skeletal muscle. Expressed in the cornea, but absent from the corneal endothelium.
  • 数据库链接：

    HGNC: 15804

    OMIM: 122000

    KEGG: hsa:58495

    STRING: 9606.ENSP00000278780

    UniGene: Hs.661013