Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. OTX1 Antibody

OTX1 Antibody

  • 货号：
    CSB-PA017298LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA017298LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA017298LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) OTX1 Polyclonal antibody
  • Uniprot No.：
    P32242
  • 基因名：
  • 别名：
    FLJ38361 antibody; Homeobox protein OTX 1 antibody; Homeobox protein OTX1 antibody; MGC15736 antibody; Orthodenticle 1 antibody; Orthodenticle homeobox 1 antibody; Orthodenticle homolog 1 antibody; Orthodenticle1 antibody; Otx 1 antibody; otx1 antibody; OTX1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein OTX1 protein (29-244AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，OTX1 Antibody (CSB-PA017298LA01HU)，的标记方式是Non-conjugated。对于OTX1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017298LB01HU OTX1 Antibody, HRP conjugated ELISA
    FITC CSB-PA017298LC01HU OTX1 Antibody, FITC conjugated
    Biotin CSB-PA017298LD01HU OTX1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
  • 基因功能参考文献：
    1. High OTX1 expression is associated with gastric cancer. PMID: 30066897
    2. We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects. PMID: 28599093
    3. OTX1 and OTX2 genes might have a role in the pathogenesis of different types of sinonasal neoplasms. PMID: 28348423
    4. Genitalia defects in these patients could result from the effect of OTX1. PMID: 25203062
    5. overexpression of OTX1 results in accumulation of colorectal cancer (CRC) cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression inhibits the proliferative and invasive capability of CRC cell lines PMID: 24388989
    6. XPO1 and OXT1 may contribute to ASD in 2p15-p16.1 deletion cases and non-deletion cases of ASD mapping to this chromosome region. PMID: 21750575
    7. established that the p53 protein directly induces OTX1 expression by acting on its promoter PMID: 21478910
    8. The early expression of OTX1 in proliferative cell layers of the human fetal brain supports the concept that this homeobox gene is important in neuronal cell development and differentiation. PMID: 20354145
    9. This study identifies OTX1 as a molecular marker for high-grade germinal center derived Non-Hodgkin Lymphoma PMID: 19893048
    10. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus candidate gene PMID: 11901358
    11. OTR1, OTX2 and CRX act as positive modulators of the BEST1 promoter in the retinal pigment epithelium. PMID: 18849347
    12. In the human fetal eye, OTX1 expression was confined to anterior retina. PMID: 19414065

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family, Bicoid subfamily
  • 组织特异性：
    Expressed in brain. Detected in the anterior part of the neural fetal retina (at protein level).
  • 数据库链接：

    HGNC: 8521

    OMIM: 600036

    KEGG: hsa:5013

    STRING: 9606.ENSP00000282549

    UniGene: Hs.734360