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  4. OTUB2 Antibody

OTUB2 Antibody

  • 货号：
    CSB-PA076030
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: CSB-PA076030(OTUB2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q96DC9
  • 基因名：
    OTUB2
  • 别名：
    C14orf137 antibody; Deubiquitinating enzyme OTUB2 antibody; FLJ21916 antibody; MGC3102 antibody; OTB2 antibody; OTU domain containing ubiquitin aldehyde binding protein 2 antibody; OTU domain, ubiquitin aldehyde binding 2 antibody; OTU domain-containing ubiquitin aldehyde-binding protein 2 antibody; OTU2 antibody; Otub2 antibody; OTUB2_HUMAN antibody; Otubain 2 antibody; Otubain-2 antibody; Ubiquitin specific processing protease OTUB2 antibody; Ubiquitin specific protease otubain 2 antibody; Ubiquitin thioesterase OTUB2 antibody; Ubiquitin-specific-processing protease OTUB2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human OTUB2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
  • 基因功能参考文献：
    1. OTUB2 fine-tunes the speed of double-strand break-induced ubiquitination so that the appropriate DNA repair pathway is chosen PMID: 24560272
    2. OTUB2 is a novel promoter of viability and insulin secretion in human beta cells. OTUB2 acts through the inhibition of NF-kappaB signalling. PMID: 23515685
    3. Data report the first crystal structure of an OTU superfamily protein, otubain 2, at 2.1 A resolution and propose a model for otubain-ubiquitin binding. PMID: 15258613
  • 蛋白家族：
    Peptidase C65 family
  • 组织特异性：
    Widely expressed. Expressed at higher level in brain.
  • 数据库链接：

    HGNC: 20351

    OMIM: 608338

    KEGG: hsa:78990

    STRING: 9606.ENSP00000203664

    UniGene: Hs.278815