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ORC4 Antibody

  • 货号：
    CSB-PA017234ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017234ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ORC4 Polyclonal antibody
  • Uniprot No.：
    O43929
  • 基因名：
  • 别名：
    cognition complex; subunit 4; S. cerevisiae; homolog of antibody; FLJ46668 antibody; HSORC4 antibody; ORC 4 antibody; ORC 4L antibody; ORC 4P antibody; ORC4 antibody; ORC4_HUMAN antibody; ORC4L antibody; ORC4L protein antibody; ORC4P antibody; Origin recognition complex subunit 4 (yeast homolog) like antibody; Origin recognition complex subunit 4 antibody; Origin recognition complex subunit 4 like (yeast) antibody; Origin recognition complex subunit 4 like antibody; origin recognition complex; subunit 4 homolog antibody; Origin recognition complex; subunit 4; S. cerevisiae; homolog-like antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Origin recognition complex subunit 4 protein (187-436AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
  • 基因功能参考文献：
    1. Since the site of one of the missense mutations in the human ORC4 alleles is conserved between humans and yeast, we sought to determine in what way this single amino acid change affects the process of chromosome replication, by introducing the comparable mutation into yeast (orc4Y232C). PMID: 29036220
    2. HsOrc4 could have a fundamental function in the process of initiation of replication by remodeling the structure of origin of replication using the energy of supercoiled DNA. PMID: 26124052
    3. compared with homozygous missense mutations, compound heterozygous mutations appeared to have a more severe effect on phenotype, causing more severe growth retardation in ORC4 PMID: 22333897
    4. identified three different mutations in the gene encoding ORC4, a component of the eukaryotic origin recognition complex, in five individuals with Meier-Gorlin syndrome PMID: 21358631
    5. DNA binding activity of HsOrc4 depends on length and structure of DNA with triplex being the protein's preferred binding target. PMID: 19690980
    6. Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding. PMID: 15910003
    7. describe 3 patients with B-cell lymphoproliferative disorders (2 with non-Hodgkin lymphoma and 1 with nonsecretory multiple myeloma) carrying a novel A286V mutation within ORC4L gene PMID: 20010161
    8. Biochemical characterization of the mouse homolog PMID: 10460412

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  • 相关疾病：
    Meier-Gorlin syndrome 2 (MGORS2)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ORC4 family
  • 数据库链接：

    HGNC: 8490

    OMIM: 603056

    KEGG: hsa:5000

    STRING: 9606.ENSP00000264169

    UniGene: Hs.558364