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OPTC Antibody

  • 货号：
    CSB-PA016362GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBM4
  • 基因名：
    OPTC
  • 别名：
    Oculoglycan antibody; OPT antibody; OPT_HUMAN antibody; OPTC antibody; Opticin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human OPTC
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils. May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily.
  • 基因功能参考文献：
    1. opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins. PMID: 22669977
    2. VEGF and hypoxia could decrease opticin protein levels in the human retinal pigment epithelium secretome, and that opticin may be an enzymatic substrate for MMP-2. PMID: 22534113
    3. localization in the human eye and genetic screen of opticin PMID: 12019215
    4. OPTC is a candidate gene for primary open-angle glaucoma PMID: 17359525
    5. OPTC and EPYC are unlikely to play a major role in high myopia. PMID: 19844586

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily
  • 组织特异性：
    Expressed in cartilage and synovial membranes (at protein level). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level). Expressed in the retinal pigment epithelium (at protein level). Expressed in synovial fibroblasts and subch
  • 数据库链接：

    HGNC: 8158

    OMIM: 605127

    KEGG: hsa:26254

    STRING: 9606.ENSP00000356191

    UniGene: Hs.632468