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OPCML Antibody

  • 货号：
    CSB-PA055401
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA055401(OPCML Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q14982
  • 基因名：
    OPCML
  • 别名：
    GM181 antibody; IgLON family member 1 antibody; IGLON1 antibody; OBCAM antibody; OPCM antibody; OPCM_HUMAN antibody; OPCML antibody; Opiate binding cell adhesion molecule antibody; Opioid binding cell adhesion molecule antibody; Opioid binding protein/cell adhesion molecule antibody; Opioid binding protein/cell adhesion molecule-like antibody; Opioid binding protein/cell adhesion molecule-like preprotein antibody; Opioid-binding cell adhesion molecule antibody; Opioid-binding protein/cell adhesion molecule antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human OPCML
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds opioids in the presence of acidic lipids; probably involved in cell contact.
  • 基因功能参考文献：
    1. Here we show that, though OPCML interacts only with HER2 and not with EGFR, the interaction of OPCML with HER2 disrupts the formation of the HER2-EGFR heterodimer, and this translates into a better response to both lapatinib and erlotinib in HER2-expressing ovarian and breast cancer cell lines PMID: 28775148
    2. Study revealed that reduced expression of OPCML might have a significant correlation with unfavorable tumor stage and differentiation, predict poor prognosis of patients with gastric cancer. OPCML had a tumor-suppressing activity possibly via AKT/GSK3beta signaling in gastric cancer. PMID: 28407749
    3. OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci PMID: 26890304
    4. OPCML plays an important role in gastric cancer, and may be a new prognostic indicator of gastric cancer. PMID: 27358143
    5. the DNA methylation levels of OPCML and SFRP1 could be potential biomarkers for diagnosis of CCA with high specificity, sensitivity, and accuracy, in particular for biopsy specimens PMID: 25652468
    6. The generation and cardiac phenotype of single and double heterozygous gene-targeted OPCML and Neurotrimin knockout mice. PMID: 24616287
    7. Detection of OPCML hypermethylation in the serum is useful for diagnosis of ovarian carcinoma. PMID: 24839818
    8. The OPCML tumor suppressor negatively regulates a specific spectrum of receptor tyrosine kinases in ovarian cancer cells by binding to their extracellular domain. PMID: 22585860
    9. A strong association was found between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population PMID: 21833655
    10. opioid binding protein/cell adhesion molecule-like promoter methylation has a role in bladder carcinoma PMID: 21273058
    11. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer PMID: 12819783
    12. Oncogenic RAS activity is directly responsible for the observed OPCML promoter hypermethylation and epigenetic gene silencing of OPCML. PMID: 16384911
    13. The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer. PMID: 17109515
    14. Hypermethylation of OPCML gene is responsible for silencing and loss of suppressor function in ovarian cancer. PMID: 17159813
    15. OPCML down-regulation occurs in the majority of brain tumours tested PMID: 17239010
    16. Results identified OPCML loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma. PMID: 17967182
    17. loss of OPCML expression occurs frequently in ovarian serous carcinoma. CpG island methylation and LOH are probably two mechanisms of OPCML inactivation PMID: 18179137
    18. OPCML gene promoter methylation may play an important role in the carcinogenesis of cervical carcinoma. OPCML may be a cervical carcinoma-associated candidate tumor suppressor gene. PMID: 18584347
    19. OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies. PMID: 18714356

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  • 相关疾病：
    Ovarian cancer (OC)
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Immunoglobulin superfamily, IgLON family
  • 数据库链接：

    HGNC: 8143

    OMIM: 167000

    KEGG: hsa:4978

    STRING: 9606.ENSP00000330862

    UniGene: Hs.4817