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OLIG1 Antibody

  • 货号：
    CSB-PA016328YA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: THP-1 whole cell lysate, Rat brain tissue, Rat lung tissue, Mouse spleen tissue, Mouse brain tissue
      All lanes: OLIG1 antibody at 2.8µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 28 kDa
      Observed band size: 28 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) OLIG1 Polyclonal antibody
  • Uniprot No.：
    Q8TAK6
  • 基因名：
    OLIG1
  • 别名：
    Basic domain helix loop helix protein class B 6 antibody; Basic domain helix loop helix protein class B6 antibody; BHLH B6 antibody; BHLHB 6 antibody; bHLHb6 antibody; bHLHe21 antibody; Class B basic helix-loop-helix protein 6 antibody; Class E basic helix-loop-helix protein 21 antibody; Olig 1 antibody; Olig1 antibody; OLIG1_HUMAN antibody; Oligo 1 antibody; Oligo1 antibody; Oligodendrocyte lineage transcription factor 1 antibody; Oligodendrocyte specific bHLH transcription factor 1 antibody; Oligodendrocyte transcription factor 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Oligodendrocyte transcription factor 1 protein (17-105AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，OLIG1 Antibody (CSB-PA016328YA01HU)，的标记方式是Non-conjugated。对于OLIG1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA016328YB01HU OLIG1 Antibody, HRP conjugated ELISA
    FITC CSB-PA016328YC01HU OLIG1 Antibody, FITC conjugated
    Biotin CSB-PA016328YD01HU OLIG1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.
  • 基因功能参考文献：
    1. Olig1 has a critical function in regulation of postnatal neural progenitor cell production in response to Noggin. PMID: 28253550
    2. This study demonstrated that increased expression of mRNA of OLIG1 in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
    3. Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility PMID: 23720758
    4. This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states. PMID: 23165259
    5. Olig1 was not expressed in freshly isolated oligodendrocytes, but is expressed from the beginning of process extension until membrane maintenance. PMID: 21446039
    6. analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus PMID: 21206754
    7. Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification. PMID: 16267213
    8. identified novel coding variants in the Olig1 gene, including a trinucleotide repeat, but found no evidence to support the hypothesis that genetic variation in Olig1 influences susceptibility to multiple sclerosis PMID: 16820418
    9. Mutations in OLIG1 and OLIG2 are not likely to be associated with this subgroup of hypomyelinating disorders. PMID: 17171653
    10. OLIG1 protein expression significantly correlates with overall survival in non-small cell lung cancer patients PMID: 17388669
    11. No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-1 expression. PMID: 17690840

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
  • 数据库链接：

    HGNC: 16983

    OMIM: 606385

    KEGG: hsa:116448

    STRING: 9606.ENSP00000371785

    UniGene: Hs.56663