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  4. ODF2 Antibody

ODF2 Antibody

  • 货号：
    CSB-PA016272GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q5BJF6
  • 基因名：
    ODF2
  • 别名：
    84 kDa outer dense fiber protein antibody; Cancer/testis antigen 134 antibody; Cenexin 1 antibody; Cenexin antibody; Cenexin1 variant 1 antibody; CT134 antibody; FLJ44866 antibody; KKT 4 antibody; KKT4 antibody; MGC111096 antibody; MGC9034 antibody; ODF 2 antibody; ODF 84 antibody; odf2 antibody; ODF2/1 antibody; ODF2/2 antibody; ODF84 antibody; ODFP2_HUMAN antibody; OTTHUMP00000022274 antibody; OTTHUMP00000022275 antibody; Outer dense fiber of sperm tail 2 antibody; Outer dense fiber of sperm tails 2 antibody; Outer dense fiber of sperm tails protein 2 antibody; Outer dense fiber of sperm tails; 84 kD antibody; Outer dense fiber protein 2 antibody; Sperm outer dense fiber major protein 2 antibody; Sperm tail structural protein antibody; Testis specific autoantigen antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ODF2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IP
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.
  • 基因功能参考文献：
    1. Cenexin controls centrosome positioning during cell migration by modulating microtubule organization and stability.Cenexin is required for spindle orientation. PMID: 26948879
    2. Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx. PMID: 22911743
    3. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. PMID: 21325031
    4. Cdk5 in the centriolar appendages mediates cenexin1 localization and primary cilia formation. PMID: 20234188
    5. Mouse and rat ODF2 protein homolog sequences and expression are compared. PMID: 9740324
    6. We propose that hCenexin1 is a critical centrosomal component whose C-terminal extension is required for proper recruitment of Plk1 and other components crucial for normal mitosis. PMID: 16966375
    7. A splice variant of hODF2 called hCenexin1, but not hODF2 itself, efficiently localizes to somatic centrosomes via a variant-specific C-terminal extension and recruits Plk1 through a Cdc2-dependent phospho-S796 motif within the extension. PMID: 19386263

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cell projection, cilium, flagellum.
  • 蛋白家族：
    ODF2 family
  • 组织特异性：
    Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails.
  • 数据库链接：

    HGNC: 8114

    OMIM: 602015

    KEGG: hsa:4957

    STRING: 9606.ENSP00000361882

    UniGene: Hs.129055