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OAS2 Antibody

  • 货号：
    CSB-PA915753
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using OAS2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P29728
  • 基因名：
  • 别名：
    (2-5'')oligo(A) synthase 2 antibody; (2-5')oligo(A) synthetase 2 antibody; 2''-5''-oligoadenylate synthase 2 antibody; 2'-5'-oligoadenylate synthetase 2 antibody; 2'-5'-oligoadenylate synthetase 2; 69/71kDa antibody; 2-5A synthase 2 antibody; 2-5A synthetase 2 antibody; 2-prime; 5-prime-oligoadenylate synthetase 2 antibody; 2-prime; 5-prime-oligoadenylate synthetase 2; 69-KD antibody; MGC78578 antibody; OAS2 antibody; OAS2_HUMAN antibody; p69 antibody; p69 OAS / p71 OAS antibody; p69OAS / p71OAS antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human OAS2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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靶点详情

  • 功能：
    Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates. Non-infected lobules would not be affected, allowing efficient pup feeding during infection.
  • 基因功能参考文献：
    1. OAS2 rs739901 5'-flanking C/A genetic polymorphisms involve the susceptibility to EV71 infection, and A allele might be a risk factor of the susceptibility to EV-71 infection. PMID: 30128873
    2. Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites. PMID: 27572959
    3. Suggest 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-zeta chain down-regulation via caspase-3 activation in oral cancer. PMID: 26595239
    4. Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population. PMID: 24594345
    5. Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL and OAS2 genes. PMID: 24328427
    6. The data suggest a possible association between OAS2 and OAS3 single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population. PMID: 21050126
    7. 2'-5'-oligoadenylate synthetase type 2 (OAS2), a dsRNA binding protein involved in the pathway that activates RNase-L, is identified as a new binding partner for NOD2. PMID: 19853919

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族：
    2-5A synthase family
  • 数据库链接：

    HGNC: 8087

    OMIM: 603350

    KEGG: hsa:4939

    STRING: 9606.ENSP00000342278

    UniGene: Hs.414332