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  4. NUP88 Antibody

NUP88 Antibody

  • 货号：
    CSB-PA004698
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using Nup88 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q99567
  • 基因名：
  • 别名：
    88 kDa nucleoporin antibody; karyoporin antibody; Nuclear pore complex protein 88 antibody; Nuclear pore complex protein Nup88 antibody; Nuclear pore complex protein88 antibody; Nucleoporin 88 antibody; Nucleoporin 88 kDa antibody; Nucleoporin 88kDa antibody; Nucleoporin Nup88 antibody; Nucleoporin88 antibody; Nucleoporin88kDa antibody; Nup 84 antibody; NUP 88 antibody; Nup84 antibody; NUP88 antibody; NUP88_HUMAN antibody; Prei 2 antibody; Prei2 antibody; Preimplantation protein 2 antibody; Preimplantation protein2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Nup88.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of nuclear pore complex.
  • 基因功能参考文献：
    1. Overexpression of the NUP88 is associated with cancer. PMID: 27636375
    2. Nup88 may be related to the occurrence of endometrial cancers and premalignant lesions PMID: 26839161
    3. These findings demonstrate that the NUP88-NUP98-RAE1-APC/CCDH1 axis contributes to aneuploidy PMID: 26731471
    4. Nup62 and Nup88 protein levels were significantly decreased upon knockdown of O-GlcNAc transferase. PMID: 23777819
    5. Serum Nup88 might be a candidate for a new biomarker implicated in the development and aggressiveness of colorectal cancer PMID: 21863385
    6. Nup88 mRNA was overexpressed in colorectal cancers and the overexpression was associated with cancer development and aggressiveness. PMID: 21896994
    7. Data suggest that a pool of Nup88 on the nuclear side of the nuclear pore complex provides a novel, unexpected binding site for nuclear lamin A. PMID: 21289091
    8. association found between myometrial invasion and Nup88 expression in endometrial carcinoma PMID: 20973273
    9. Gambogic acid exerts its anti-leukemia effects by regulating the expression and distribution of nucleoporin Nup88. PMID: 17828493
    10. proper expression of Nup88 is critical for preventing aneuploidy formation and tumorigenesis. PMID: 20497554
    11. High Nup88 mRNA expression levels correlated with ductal and tubular histology, nuclear grade 3, absence of hormone receptors, expression of c-erb-B2 oncogene and mutant p53 protein, high proliferation, DNA aneuploidy, and axillary node invasion. PMID: 14999780
    12. A monoclonal antibody for Nup88 in an experimental model for studying the role played by Nup88 during cell development and differentiation. PMID: 15300515
    13. the Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export PMID: 16675447
    14. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. PMID: 17007055
    15. The antitumor activity of deguelin was related to up-regulating the expression of Nup98 and down-regulating Nup88 protein. PMID: 17650673
    16. The formation of high molecular mass complexes containing importin-alpha, Nup153 and Nup88 is increased upon oxidant treatment. PMID: 18068677
    17. Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes. PMID: 18606815
    18. Nup88 is significantly overexpressed in high-grade CIN lesions and ISCC compared with normal ectocervical squamous epithelia and CIN1. PMID: 19751906

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  • 亚细胞定位：
    Nucleus, nuclear pore complex.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 8067

    OMIM: 602552

    KEGG: hsa:4927

    STRING: 9606.ENSP00000458954

    UniGene: Hs.584784