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  4. NUP160 Antibody

NUP160 Antibody

  • 货号：
    CSB-PA008350
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Hela cells using Nup160 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q12769
  • 基因名：
    NUP160
  • 别名：
    160 kDa nucleoporin antibody; DKFZp686M14102 antibody; FLJ22583 antibody; KIAA0197 antibody; MGC150678 antibody; MGC150679 antibody; NU160_HUMAN antibody; Nuclear pore complex protein Nup160 antibody; Nucleoporin 160kD antibody; Nucleoporin 160kDa antibody; Nucleoporin Nup160 antibody; NUP 160 antibody; NUP120 antibody; Nup160 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Nup160.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a component of the nuclear pore complex (NPC). Involved in poly(A)+ RNA transport.
  • 基因功能参考文献：
    1. Nup107-160 complex and its partner Elys dynamically colocalize with Nup98 and CRM1 into endogenous GLFG bodies present in specific HeLa sublines. PMID: 25904327
    2. transcriptome sequencing of patient-derived angiosarcoma cells, identified a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined. PMID: 26527604
    3. The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. PMID: 22031293
    4. The interactions of Nup160 with Pom121 and are predicted to assist in the formation of the nuclear pore and the anchoring of the Nuclear pore complexes to the pore membrane. PMID: 20974814
    5. A major function of the Nup107 complex in mitosis is to ensure the proper localization of the chromosome passenger complex at the centromere. PMID: 19864462
    6. Data show that Nup107-160 promotes spindle assembly through Ran-GTP-regulated nucleation of microtubules by gamma-TuRC at kinetochores, and reveal a relationship between nucleoporins and the microtubule cytoskeleton. PMID: 20081840
    7. Data show that structure-guided sequence comparison of Nup160 and Saccharomyces cerevisiae Nup120 strongly suggests that both proteins adopt the same unique fold despite a low sequence identity of 10%. PMID: 19576787
    8. Nup107-160 complex is dynamic in mitosis and that it promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores. PMID: 16807356
    9. phosphorylation does not affect interactions within the Nup107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins PMID: 17360435
    10. These data thus provide the first molecular clues underlying the function of the human Nup107-160 complex at kinetochores. PMID: 17363900

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  • 亚细胞定位：
    Nucleus, nuclear pore complex.
  • 数据库链接：

    HGNC: 18017

    OMIM: 607614

    KEGG: hsa:23279

    STRING: 9606.ENSP00000367721

    UniGene: Hs.643526