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NUDT2 Antibody

  • 货号：
    CSB-PA2105ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA2105ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA2105ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NUDT2 Polyclonal antibody
  • Uniprot No.：
    P50583
  • 基因名：
    NUDT2
  • 别名：
    2310051L06Rik antibody; 5''''-P1 antibody; AA939917 antibody; Ap4A hydrolase 1 antibody; Ap4A hydrolase antibody; AP4A_HUMAN antibody; Ap4Aase antibody; APAH 1 antibody; APAH1 antibody; Bis(5' nucleosyl) tetraphosphatase [asymmetrical] antibody; Bis(5''-nucleosyl)-tetraphosphatase [asymmetrical] antibody; Diadenosine 5'' antibody; Diadenosine 5',5''' P1,P4 tetraphosphate asymmetrical hydrolase antibody; Diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase antibody; Diadenosine tetraphosphatase antibody; EC 3.6.1.17 antibody; MGC10404 antibody; Nucleoside diphosphate linked moiety X motif 2 antibody; Nucleoside diphosphate-linked moiety X motif 2 antibody; nudix (nucleoside diphosphate linked moiety X)-type motif 2 antibody; Nudix motif 2 antibody; Nudix-type motif 2 antibody; NUDT 2 antibody; NUDT2 antibody; OTTHUMP00000021256 antibody; OTTHUMP00000021257 antibody; OTTHUMP00000021258 antibody; OTTHUMP00000021259 antibody; P4-tetraphosphate asymmetrical hydrolase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Bis(5\'-nucleosyl)-tetraphosphatase [asymmetrical] protein (1-147AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP. Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro.
  • 基因功能参考文献：
    1. NUDT2 is a novel complex formation enhancing factor regulating mTORC1-Rag GTPase signaling that is crucial for cell growth control. PMID: 28089905
    2. Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap4A). We have examined this directly by a comparative RNA-Seq analysis of KBM-7 chronic myelogenous leukemia cells and KBM-7 cells in which the NUDT2 Ap4A hydrolase gene had been disrupted (NuKO cells), causing a 175-fold increase in intracellular Ap4A. PMID: 27144453
    3. This paper presents the crystal structure of wild-type and E58A mutant human Ap4A hydrolase. PMID: 23384440
    4. High NUDT2 is associated with breast carcinoma. PMID: 20533549
    5. In this study the s present data demonstrating that the SARS-CoV 7a protein interacts with human Ap4A-hydrolase (asymmetrical diadenosine tetraphosphate hydrolase, EC 3.6.1.17). PMID: 20144233
    6. crystallographic structure and substrate-binding mechanism of Ap4A hydrolase PMID: 15596429
    7. NMR resonance assignments PMID: 15772762

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  • 蛋白家族：
    Nudix hydrolase family
  • 数据库链接：

    HGNC: 8049

    OMIM: 602852

    KEGG: hsa:318

    STRING: 9606.ENSP00000338397

    UniGene: Hs.493767