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NT5C1A Antibody

  • 货号：
    CSB-PA055423
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9BXI3
  • 基因名：
    NT5C1A
  • 别名：
    5' nucleotidase cytosolic IA antibody; 5NT1A_HUMAN antibody; AMP specific 5' NT antibody; CN I antibody; CN IA antibody; cN-I antibody; cN-IA antibody; CN1 antibody; cN1A antibody; cNI antibody; cNIA antibody; Cytosolic 5' nucleotidase 1A antibody; Cytosolic 5' nucleotidase IA antibody; Cytosolic 5' nucleotidase type 1A antibody; Cytosolic 5''-nucleotidase 1A antibody; Cytosolic 5''-nucleotidase IA antibody; MGC119199 antibody; MGC119201 antibody; NT5C1A antibody; nucleotidase; 5-prime; cytosolic; IA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NT5C1A.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
  • 基因功能参考文献：
    1. Individual missense changes in NT5C1A showed considerable variation in response to the different nucleoside analogs tested. PMID: 26906009
    2. seropositivity to the NT5c1A antibody is associated with greater motor and functional disability in sporadic inclusion body myositis PMID: 25857661
    3. Anti-NT5C1A is a common target of circulating autoantibodies in autoimmune diseases. PMID: 25892010
    4. NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle PMID: 21873433
    5. overexpression of 5'-nucleotidase inhibits Natural Killer cell cytotoxicity to ameliorate rejection after xenotransplantation PMID: 15888028
    6. deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I are regulated in a cell cycle-dependent manner in MOLT-4 cells PMID: 17065091
    7. There was no correlation between expression of cN-I and fiber type. PMID: 19352542

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    5'-nucleotidase type 3 family
  • 组织特异性：
    Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.
  • 数据库链接：

    HGNC: 17819

    OMIM: 610525

    KEGG: hsa:84618

    STRING: 9606.ENSP00000235628

    UniGene: Hs.307006