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NSMF Antibody

  • 货号：
    CSB-PA859576ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA859576ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NSMF Polyclonal antibody
  • Uniprot No.：
    Q6X4W1
  • 基因名：
    NSMF
  • 别名：
    Nasal embryonic LHRH factor antibody; Nasal embryonic luteinizing hormone releasing hormone factor antibody; Nasal embryonic luteinizing hormone-releasing hormone factor antibody; Nelf antibody; NELF_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human NMDA receptor synaptonuclear signaling and neuronal migration factor protein (251-530AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
  • 基因功能参考文献：
    1. The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization. PMID: 24316376
    2. a model in which NELF recruits Pcf11 and NCoR1-GPS2-HDAC3 to paused RNAP II, reinforcing repression of HIV transcription and establishing a critical checkpoint for HIV transcription and latency. PMID: 23884411
    3. NELF is associated with normosmic idiopathic hypogonadotropic hypogonadism and Kallmann syndrome, either singly or in combination with a mutation in another gene. PMID: 21300340
    4. our findings implicate NELF as a nuclear protein involved in the developmental function of the reproductive axis. PMID: 20025934
    5. 12% of Kallman syndrome males have KAL1 deletions, but intragenic deletions of the FGFR1, GNRH1, GNRHR, GPR54 and NELF genes are uncommon in Idiopathic hypogonadotropic hypogonadism/Kallman syndrome. PMID: 18463157

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  • 相关疾病：
    Hypogonadotropic hypogonadism 9 with or without anosmia (HH9)
  • 亚细胞定位：
    Nucleus. Nucleus envelope. Nucleus membrane. Nucleus matrix. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Membrane.
  • 蛋白家族：
    NSMF family
  • 组织特异性：
    Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney.
  • 数据库链接：

    HGNC: 29843

    OMIM: 608137

    KEGG: hsa:26012

    STRING: 9606.ENSP00000360530

    UniGene: Hs.455336