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NRCAM Antibody

  • 货号：
    CSB-PA016074LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA016074LA01HU diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA016074LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of 293 cells with CSB-PA016074LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NRCAM Polyclonal antibody
  • Uniprot No.：
    Q92823
  • 基因名：
    NRCAM
  • 别名：
    Bravo antibody; hBravo antibody; Neuronal cell adhesion molecule antibody; Neuronal surface protein Bravo antibody; Ng CAM related antibody; Ng-CAM-related antibody; NgCAM related cell adhesion molecule antibody; NgCAM-related cell adhesion molecule antibody; Nr CAM antibody; Nr-CAM antibody; Nrcam antibody; NRCAM_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Neuronal cell adhesion molecule protein (1194-1299AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NRCAM Antibody (CSB-PA016074LA01HU)，的标记方式是Non-conjugated。对于NRCAM Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA016074LB01HU NRCAM Antibody, HRP conjugated ELISA
    FITC CSB-PA016074LC01HU NRCAM Antibody, FITC conjugated
    Biotin CSB-PA016074LD01HU NRCAM Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
  • 基因功能参考文献：
    1. Increased gene expression of NrCAM may be used as a potential diagnostic marker for papillary thyroid cancer. PMID: 27732334
    2. A high level of Nr-CAM expression is associated with favorable tumor phenotype and reduced risk of prostate cancer recurrence. PMID: 23338556
    3. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM PMID: 21876539
    4. mechanisms of NrCAM participation in development and how these might be perturbed in disorders are reviewed. [review] PMID: 22182708
    5. Nr-CAM protein expression is upregulated in colorectal cancer tissues; Nr-CAM overexpression is an independent marker of poor prognosis among advanced CRC patients, and a possible predictive marker for non-beneficence to 5-fluorouracil-based chemotherapy PMID: 21718388
    6. Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM PMID: 11866539
    7. induction of Nr-CAM transcription plays a role in melanoma and colon cancer tumorigenesis PMID: 12183361
    8. NrCAM is overexpressed in human papillary thyroid carcinoma at the mRNA and protein levels, whatever the tumour stage. PMID: 17667921
    9. Distinct cytokeratin 7, cytokeratin 19, & neuronal cell adhesion molecule staining patterns are seen in hepatic adenoma & focal nodular hyperplasia possibly suggest activation of different subsets of hepatic progenitor/stem cell. PMID: 18602664
    10. our results indicated that the NRCAM gene is one of the strong candidate genes for autism PMID: 18664314

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily, L1/neurofascin/NgCAM family
  • 组织特异性：
    Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
  • 数据库链接：

    HGNC: 7994

    OMIM: 601581

    KEGG: hsa:4897

    STRING: 9606.ENSP00000368314

    UniGene: Hs.21422