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NRARP Antibody

  • 货号：
    CSB-PA016069LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA016069LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA016069LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NRARP Polyclonal antibody
  • Uniprot No.：
    Q7Z6K4
  • 基因名：
    NRARP
  • 别名：
    MGC61598 antibody; Notch regulated ankyrin repeat containing protein antibody; NOTCH regulated ankyrin repeat protein antibody; Notch-regulated ankyrin repeat-containing protein antibody; nrarp antibody; NRARP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Notch-regulated ankyrin repeat-containing protein (1-114AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NRARP Antibody (CSB-PA016069LA01HU)，的标记方式是Non-conjugated。对于NRARP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA016069LB01HU NRARP Antibody, HRP conjugated ELISA
    FITC CSB-PA016069LC01HU NRARP Antibody, FITC conjugated
    Biotin CSB-PA016069LD01HU NRARP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain.
  • 基因功能参考文献：
    1. High NRARP expression is associated with papillary thyroid carcinoma progression. PMID: 28207739
    2. Downregulation of NRARP expression exerts significant antitumor activities against cell growth and invasion of thyroid cancer, that suggests a potential role of NRARP in thyroid cancer targeted therapy. PMID: 27364790
    3. NRARP may stimulate cell proliferation in human breast cancer. PMID: 24778018
  • 蛋白家族：
    NRARP family
  • 数据库链接：

    HGNC: 33843

    KEGG: hsa:441478

    STRING: 9606.ENSP00000349041

    UniGene: Hs.535075