NPRL3 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) NPRL3 Polyclonal antibody
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Uniprot No.:Q12980
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基因名:
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别名:otein antibody; Alpha-globin regulatory element-containing gene protein antibody; C16ORF35 antibody; CGTHBA antibody; Conserved gene telomeric to alpha globin cluster antibody; HS 40 antibody; MARE antibody; Nitrogen permease regulator 3-like protein antibody; Nitrogen permease regulator-like 3 (S. cerevisiae) antibody; NPR3 antibody; NPRL3 antibody; NPRL3_HUMAN antibody; Protein CGTHBA antibody; RMD11 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human GATOR complex protein NPRL3 protein (349-482AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,NPRL3 Antibody (CSB-PA619643LA01HU),的标记方式是Non-conjugated。对于NPRL3 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:200-1:500 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
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基因功能参考文献:
- This study demonstrated that mutation of NPRL3 in familial focal epilepsies and focal cortical dysplasia. PMID: 27173016
- NPRL3 mutations are significant cause of focal epilepsy. PMID: 26505888
- Mutations in NPRL3 are a novel cause of familial cortical dysplasia. PMID: 26285051
- NPRL3 is a candidate gene for harbouring mutations in individuals with developmental abnormalities of the cardiovascular system. PMID: 22538705
- NPRL3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
- C16orf35 can modulate differentially the specific activities of selected p73 isoforms. PMID: 19666006
收起更多
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相关疾病:Epilepsy, familial focal, with variable foci 3 (FFEVF3)
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亚细胞定位:Lysosome membrane.
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蛋白家族:NPR3 family
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组织特异性:Widely expressed. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes.
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数据库链接:
HGNC: 14124
OMIM: 600928
KEGG: hsa:8131
STRING: 9606.ENSP00000382834
UniGene: Hs.19699