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NPPC Antibody

  • 货号：
    CSB-PA136609
  • 规格：
    ￥1100
  • 图片：
    • The image is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA136609(NPPC Antibody) at dilution 1/70. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P23582
  • 基因名：
    NPPC
  • 别名：
    ANFC_HUMAN antibody; C type natriuretic peptide precursor antibody; CNP antibody; CNP-53 antibody; CNP2 antibody; Natriuretic peptide C antibody; Natriuretic peptide precursor C antibody; NPPC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human NPPC
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3.
  • 基因功能参考文献：
    1. two heterozygous NPPC mutations, located in the highly conserved ring, were identified; mutations cause autosomal dominant short stature in humans PMID: 28661490
    2. This study showed that Plasma concentrations of amino-terminal proCNP are depressed in Parkinson's Disease. PMID: 28673612
    3. C-type natriuretic peptide (CNP)administration significantly decreased the secretion and expression of MMP-2 and MMP-9 in the cultured mesangial cells ; (2) the secretion and expression of TIMP-1 progressively elevated after treatment with CNP for 24 and 48 h, whereas declined at later time point; (3) CNP expression was negatively correlated with MMP-2 and MMP-9 expression. PMID: 28554303
    4. CNP level in pericardial fluid is a more sensitive marker of LV dysfunction than CNP levels in plasma in coronary artery disease patients undergoing coronary artery bypass grafting. PMID: 26962968
    5. Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor receptor B; CNP = C-type natriuretic peptide) PMID: 28450398
    6. CNP may play a more important role than BNP and ANP related peptides, as risk marker of obesity PMID: 27376982
    7. CNP and FGF-23 act through a close or reciprocal pathway and are in agreement with recent studies demonstrating a down-regulatory role of the mitogen-activated protein kinase activity by CNP PMID: 26459742
    8. CNP/NPR-B can affect sperm motility and acrosome reaction, thus regulating the reproductive function of males PMID: 25926602
    9. CNP levels rose after paroxysmal supraventricular tachycardia and continued to rise after the termination. PMID: 26801306
    10. examined whether CNP reduces hyaluronan production and export via members of the multidrug resistance protein (MRP) and diminishes pro-inflammatory effects in chondrocytes PMID: 26307537
    11. Plasma CNP might serve as a useful predictor for the therapeutic efficacy of metoprolol on postural tachycardia syndrome in children. PMID: 25811760
    12. CNP/proCNP could be new markers in human prostate cancer PMID: 25808436
    13. This case supports the concept that NPPC is overexpressed because of the loss of a specific negative regulatory control in the normal chromosomal location, and demonstrates the effectiveness of targeted resequencing in the mapping of breakpoints. PMID: 25728306
    14. An increased level of NT-pro CNP is a promising non-invasive marker of hepatitis C related CLD complications and disease progression. PMID: 26485840
    15. CNP effectively attenuated LPS-induced endothelial activation by inhibiting the NF-kappaB and p38 signaling pathways. PMID: 25096521
    16. In achondroplasia, hypochondroplasia, and thanatophoric dysplasia, elevated plasma levels of proCNP products suggest the presence of tissue resistance to CNP. PMID: 25387261
    17. Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium. PMID: 24099862
    18. This is the first report of a circulating preproCNP derived signal peptide. PMID: 24845564
    19. Gene expression of C-type natriuretic peptide and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects PMID: 22884919
    20. C-type natriuretic peptide expression increases in human leukocytes of patients with chronic heart failure as a function of clinical disease severity. PMID: 23911666
    21. Acute inflammation in young children potently reduces CNP production. PMID: 23732776
    22. these observations suggest that CNP and its specific receptor, NPR-B, can play a very important role in regulating cardiac hypertrophy and remodeling, indicating NPR-B as a new potential drug target for the treatment of cardiovascular disease. PMID: 23262354
    23. DNA sequence analysis, single nucleotide polymorphism characterization and miRNA binding site identification in the 3'UTR of the human NPPC gene. PMID: 23542429
    24. CNP synthesis (as measured by NTproCNP levels in plasma) is closely related to linear growth in healthy children at all ages. We propose NTproCNP as a biomarker of linear growth. PMID: 22435455
    25. CNP production and clearance are increased in boys with Klinefelter syndrome. PMID: 22962429
    26. NPR2 expression in normal human fetal and adult pituitaries and adenomatous pituitary tissue and suggest a role for these receptors in both pituitary development and oncogenesis. PMID: 22645228
    27. Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery. PMID: 22421372
    28. Serum NT-proCNP is elevated in advanced liver diseases and has prognostic value in cirrhotic patients. PMID: 22285383
    29. Continuous intravenous infusion of C-type natriuretic peptide did not attenuate the development of pulmonary hypertension caused by hypoxia and VEGF receptor blockade. PMID: 21820448
    30. The concentrations of amino-terminal pro-C-type natriuretic peptide in rheumatoid arthritis patients were significantly increased when compared to healthy controls. PMID: 20934962
    31. 56-year-old woman with Budd-Chiari syndrome who underwent liver transplantaation in whom heart failure was successfully managed using serial monitoring of BNP concentrations. PMID: 20832589
    32. The study indicates functional signaling by B- and C-type natriuretic peptides in vascular endothelial cells, supporting possible roles of these mediators in regulating endothelial cell function. PMID: 20085572
    33. Results support role of TSC22D1 as an enhancer of CNP transcription and suggest that TGF-beta-induced upregulation of CNP expression in smooth muscle may be mediated in part by increased transcription of TSC22D1. PMID: 20802130
    34. NT-proCNP was associated with the endosteal apposition of bone at the distal forearm in females with a persistent eating disorder PMID: 20551602
    35. Data suggest that decreased plasma proCNP concentration in idiopathic intracranial hypertension may reflect endothelial dysregulation of vascular tone and may be a marker in this disease. PMID: 20553977
    36. CNP/NPR-B signaling pathway is activated during TGF-beta1 induced chondrogenic differentiation of human trabecular bone-derived mesenchymal stem cells. PMID: 20721606
    37. new proCNP assay shows that proCNP is abundantly present in human seminal plasma and that seminal proCNP is secreted from the prostate gland and/or the seminal vesicles. PMID: 20797397
    38. Our data demonstrates that generation of CNP is not enhanced under heart failure condition like Chagas disease; CNP rise by severe HF is caused by its less degradation that is independent of neutral endopeptidase activity PMID: 20090473
    39. findings demonstrate that CNP metabolism is altered in patients with nephrotic syndrome and support the hypothesis that activation of renal CNP can be partially offset by a low-protein diet PMID: 12167597
    40. CNP G2628A polymorphism made an even greater contribution to hypertension in the younger subpopulation. PMID: 12452325
    41. human pro-CNP processing requires furin PMID: 12736257
    42. Particulate guanylate cyclase activation by CNP induces a post-transductional down-regulation of soluble guanylate cyclase by a mechanism involving PKG and the proteasome pathway PMID: 14654233
    43. The first intron in the CNP sequence does not contain any additional enhancer-binding sites. However, the signal sequence is indispensable for secretion of CNP and its appropriate physiological function. PMID: 15231517
    44. BNP levels appear to be elevated in coronary disease, especially in acute coronary syndromes, even in the absence of systolic dysfunction PMID: 15598085
    45. discussion of C-type natriuretic peptide and guanylyl cyclase B receptor [review] PMID: 15911070
    46. NT-proCNP may have a role in growth velocity and bone formation PMID: 16006435
    47. CNP is capable of autoregulating the expression of its cognate receptor. PMID: 16109786
    48. CNP is a modulator of acute inflammation in the blood vessel wall characterized by leukocyte and platelet activation, mediated, at least in part, via suppression of P-selectin expression. PMID: 16179391
    49. report suggests that in humans, platelet-derived growth factor(PDGF) and downstream activation of protein kinase C could represent an important control for natriuretic peptide precursor C expression in vascular smooth muscle PMID: 16777970
    50. There is a discordant expression of NPPC in newborn infants of mothers with type 1 diabetes. PMID: 17289171

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Natriuretic peptide family
  • 组织特异性：
    [CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level).
  • 数据库链接：

    HGNC: 7941

    OMIM: 600296

    KEGG: hsa:4880

    STRING: 9606.ENSP00000295440

    UniGene: Hs.247916