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NPL Antibody

  • 货号：
    CSB-PA015994GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BXD5
  • 基因名：
    NPL
  • 别名：
    0610033B02Rik antibody; C112 antibody; C1orf13 antibody; Dihydrodipicolinate synthase antibody; Dihydrodipicolinate synthetase homolog 1 antibody; MGC149582 antibody; MGC61869 antibody; N-acetylneuraminate lyase antibody; N-acetylneuraminate pyruvate-lyase antibody; N-acetylneuraminic acid aldolase antibody; NAL antibody; NALase antibody; NPL antibody; NPL_HUMAN antibody; NPL1 antibody; RP11-249O6.1 antibody; Sialate lyase antibody; Sialate-pyruvate lyase antibody; Sialic acid aldolase antibody; Sialic acid lyase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NPL
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Experiments show the true substrate is aceneuramate (linearized Neu5Ac).
  • 基因功能参考文献：
    1. an NPL splice variant is mainly expressed in human liver, kidney and peripheral blood leukocytes PMID: 16147865
    2. 3D structure model of N-acetylneuraminate lyase from human (hNAL, EC 4.1.3.3) was created and refined PMID: 19057931
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    DapA family, NanA subfamily
  • 组织特异性：
    Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.
  • 数据库链接：

    HGNC: 16781

    OMIM: 611412

    KEGG: hsa:80896

    STRING: 9606.ENSP00000258317

    UniGene: Hs.496969