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NOSTRIN Antibody

  • 货号：
    CSB-PA015948GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8IVI9
  • 基因名：
    NOSTRIN
  • 别名：
    BM247 antibody; BM247 homolog antibody; DaIP2 antibody; eNOS-trafficking inducer antibody; mDaIP2 antibody; MGC20702 antibody; Nitric oxide synthase traffic inducer antibody; Nitric oxide synthase trafficker antibody; NOSTN_HUMAN antibody; Nostrin antibody; RP23-431D4.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NOSTRIN
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
  • 基因功能参考文献：
    1. The suggest that scores obtained with the worst nostril are the most efficient in detecting an olfactory disorder. PMID: 28981819
    2. NOSTRIN inhibited production of nitric oxide (NO) by suppressing the activation of endothelial nitric oxide synthase (eNOS). PMID: 27401251
    3. no significant difference in serum level associated with preeclampsia or intrauterine growth restriction PMID: 24588201
    4. This study showed that overexpression of NOSTRIN had a significant effect on eNOS activity in HUVECs and resulted in significant cellular damage. PMID: 23592143
    5. The expression of NOSTRIN is decreased, while the activity of eNOS and the level of NO2-/NO3- increased in the testis tissue of azoospermia patients. PMID: 21351530
    6. Results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN. PMID: 21183735
    7. NOSTRIN expression was increased in umbilical vessel of women with pre-eclampsia. PMID: 19399414
    8. NOSTRIN modulates nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. PMID: 12446846
    9. NOSTRIN may facilitate endocytosis of endothelial nitric oxide synthase by coordinating the function of dynamin and the actin nucleation promoting factor N-WASP. PMID: 16234328
    10. A ternary complex between NOSTRIN, caveolin-1, and eNOS mediates translocation of eNOS, with important implications for the activity and availability of eNOS in the cell. PMID: 16807357
    11. results suggest that nuclear NOSTRINbeta may negatively regulate transcription of the NOSTRIN gene PMID: 18980613

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; [Isoform 3]: Nucleus.
  • 组织特异性：
    Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).
  • 数据库链接：

    HGNC: 20203

    OMIM: 607496

    KEGG: hsa:115677

    UniGene: Hs.189780