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NMT1 Antibody

  • 货号：
    CSB-PA015900LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA015900LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NMT1 Polyclonal antibody
  • Uniprot No.：
    P30419
  • 基因名：
  • 别名：
    Alternative, short form NMT S antibody; EC 2.3.1.97 antibody; Glycylpeptide N tetradecanoyltransferase 1 antibody; Glycylpeptide N-tetradecanoyltransferase 1 antibody; Long form, NMT L antibody; Myristoyl CoA:protein N myristoyltransferase 1 antibody; Myristoyl-CoA:protein N-myristoyltransferase 1 antibody; N myristoyltransferase 1 antibody; NMT 1 antibody; NMT antibody; nmt1 antibody; NMT1_HUMAN antibody; Peptide N myristoyltransferase 1 antibody; Peptide N-myristoyltransferase 1 antibody; Type I N myristoyltransferase antibody; Type I N-myristoyltransferase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Glycylpeptide N-tetradecanoyltransferase 1 protein (1-158AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NMT1 Antibody (CSB-PA015900LA01HU)，的标记方式是Non-conjugated。对于NMT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015900LB01HU NMT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA015900LC01HU NMT1 Antibody, FITC conjugated
    Biotin CSB-PA015900LD01HU NMT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
  • 基因功能参考文献：
    1. Genetic and pharmacologic evidence that inhibiting the N-myristoyltransferase NMT1 suppresses cell-cycle progression, proliferation, and malignant growth of prostate cancer cells. PMID: 29038344
    2. These observations point at a previously unrecognized contribution of calnexin to the retention of NMT1 at the ER membrane. PMID: 26603938
    3. findings suggest that both NMT1 and hnRNP A2/B1 take part in the regulation of HIV-1 RNA expression through their mutual opposite effects on the viral RNA expression in HIV-1-producing cells PMID: 26074144
    4. we propose a model of the Nef:NMT complex in which only the myristoyl moiety holds the two proteins together in complex and speculate that perhaps NMT chaperones Nef to the membrane and thereby protects the myristic acid group from the cytosol PMID: 21449607
    5. In this study, we found decreases in the mRNA levels of human NMT isoforms and the NMT activities in the course of HIV-1 infection in the human T-cell line PMID: 12220649
    6. role of HSC70 in the regulation of NMT PMID: 15156568
    7. NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation PMID: 16123142
    8. Elevated N-myristoyltransferase activity is associated with oral squamous cell carcinoma PMID: 17549352
    9. N-myristoyltransferase may have a role in progression of colonic neoplasms PMID: 18021392
    10. Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence. PMID: 18089753
    11. These results strongly suggest that HIV-1 production is specifically associated with hNMT1, particularly hNMT1(L), but not with hNMT2 in vivo, contributing to the understanding of a step in HIV-1 replication. PMID: 18248763

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    NMT family
  • 组织特异性：
    Heart, gut, kidney, liver and placenta.
  • 数据库链接：

    HGNC: 7857

    OMIM: 160993

    KEGG: hsa:4836

    STRING: 9606.ENSP00000258960

    UniGene: Hs.532790