Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. NME4 Antibody

NME4 Antibody

  • 货号：
    CSB-PA015889ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA015889ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NME4 Polyclonal antibody
  • Uniprot No.：
    O00746
  • 基因名：
    NME4
  • 别名：
    metastatic inhibition factor NM23H4 antibody; mitochondrial antibody; NDK antibody; NDKM_HUMAN antibody; NDP kinase antibody; NDP kinase D antibody; NDP kinase, mitochondrial antibody; NDPK D antibody; NDPKD antibody; nm23 H4 antibody; nm23-H4 antibody; NM23D antibody; NM23H4 antibody; Nm23M4 antibody; NME/NM23 nucleoside diphosphate kinase 4 antibody; NME4 antibody; Non metastatic cells 4 protein expressed in antibody; Non metastatic protein 23, homolog 4 antibody; Nucleoside diphosphate kinase D antibody; Nucleoside diphosphate kinase, mitochondrial antibody; Nucleoside diphosphate kinase, mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nucleoside diphosphate kinase, mitochondrial protein (1-187AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity. Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration. Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria. In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling.
  • 基因功能参考文献：
    1. NDPK-D has an important role in the early stages of mitophagy as induced by carbonyl cyanide m-chlorophenylhydrazone as well as by PINK1-Parkin-independent stimuli such as rotenone and 6-hydroxydopamine. PMID: 26742431
    2. Mitochondrial NM23-H4/NDPK-D: a bifunctional nanoswitch for bioenergetics and lipid signaling PMID: 25231795
    3. miR-196 performed it's their function by inhibiting NME4 expression and further activating p-JNK, suppressing TIMP1, and augmenting MMP1/9. PMID: 25233933
    4. Nm23-H4 acts as a lipid-dependent mitochondrial switch with dual function in phosphotransfer serving local GTP supply and cardiolipin transfer for apoptotic signaling and putative other functions PMID: 23150663
    5. High expression of ERCC1, FLT1, NME4 and PCNA in myelodysplastic syndrome was associated with poor prognosis and disease progression along the sequence of 5q-syndrome/RCMD/RAEB/de novo AML PMID: 18604718

    显示更多

    收起更多

  • 亚细胞定位：
    Mitochondrion intermembrane space; Peripheral membrane protein. Mitochondrion matrix.
  • 蛋白家族：
    NDK family
  • 组织特异性：
    Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.
  • 数据库链接：

    HGNC: 7852

    OMIM: 601818

    KEGG: hsa:4833

    STRING: 9606.ENSP00000219479

    UniGene: Hs.9235