Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. NLRP12 Antibody

NLRP12 Antibody

  • 货号：
    CSB-PA069966
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA069966(NLRP12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA069966(NLRP12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P59046
  • 基因名：
  • 别名：
    CLR19.3 antibody; FCAS2 antibody; Monarch 1 antibody; Monarch-1 antibody; NACHT, leucine rich repeat and PYD containing 12 antibody; NACHT, LRR and PYD containing protein 12 antibody; NACHT, LRR and PYD domains-containing protein 12 antibody; NAL12_HUMAN antibody; NLR family, pyrin domain containing 12 antibody; NLRP12 antibody; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 antibody; OTTHUMP00000067227 antibody; PAN6 antibody; PYPAF7 antibody; PYRIN containing APAF1 like protein 7 antibody; PYRIN-containing APAF1-like protein 7 antibody; Regulated by nitric oxide antibody; RNO antibody; RNO2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human NLRP12
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation. Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue.
  • 基因功能参考文献：
    1. Patients with NLRP12 germline mutations and diagnosis of NLRP12-related autoinflammatory disease demonstrated highly variable clinical phenotypes. PMID: 29500522
    2. report the crystal structure of NLRP12 PYD domain at 1.70 A fused with an maltose-binding protein (MBP) tag PMID: 29293680
    3. all of the reported mutations were found to have occurred in a highly conserved region in the NACHT domain coding sequence in NLRP12 exon 3, suggesting that a screening strategy for Familial cold autoinflammatory syndrome should focus on this area of the gene PMID: 27314497
    4. The novel findings reveal the critical role of NLRP12-IL-17A-CXCL1 axis in host defense by modulating neutrophil recruitment against Klebsiella pneumoniae. PMID: 26349659
    5. This process involved the upregulation of NLRP12. PMID: 26329693
    6. Variants of NLRP12 were associated with common variable immunodeficiency. PMID: 26122175
    7. NLRP12/NLRP3-dependent activation of caspase-1 is likely to be a key event in mediating systemic production of IL-1beta and hypersensitivity to secondary bacterial infection during malaria. PMID: 24453977
    8. The genetics, expression and roles of NLRP12 in inflammatory signaling, host defense, and carcinogenesis are reviewed. Review. PMID: 25249449
    9. This study suggested that NLRP12 mutations might account for a small fraction of common variable immunodeficiency patients with severe auto-inflammatory complications. PMID: 25064839
    10. We will focus on NLRP6 and NLRP12. PMID: 24338634
    11. Letter: NLRP12 mutations associated with familial cold autoinflammatory syndrome 2 in Italian patients. PMID: 24064030
    12. Even with a variable range of associated manifestations, the extreme sensitivity to cold represents the main clinical hallmark in an individual carrying the p.D294E mutation of the NLRP12 gene. PMID: 21360512
    13. The s report the first in vitro confirmed non-homotypic interaction between NLRP12 pyrin domain and the pro-apoptotic protein Fas-associated factor 1 (FAF-1), which links the innate immune system to apoptotic signaling. PMID: 21978668
    14. NLRP12 missense mutation in periodic fever syndromes; study provides evidence of deleterious effect of an NLRP12 missense mutation; this newly identified molecular defect emphasizes the crucial role played by NLRP12 in autoinflammation PMID: 21538323
    15. regulates activation of NF-kappa B and caspase-1-dependent cytokine processing PMID: 12019269
    16. Monarch-1 enhances nonclassical and classical major histocompatibility complex class I expression at the level of the promoter, RNA, and protein expression. PMID: 12759408
    17. Monarch-1 associates with IRAK-1 but not MyD88, resulting in the blockage of IRAK-1 hyperphosphorylation PMID: 16203735
    18. Monarch-1 inhibits CD40-mediated activation of NF-kappaB via the non-canonical pathway in human monocytes. This inhibition stems from the ability of Monarch-1 to associate with and induce proteasome-mediated degradation of NF-kappaB inducing kinase PMID: 17237370
    19. Heat shock protein 90 is a critical regulator of Monarch-1 anti-inflammatory activity PMID: 17947705
    20. ATP binding by NLRP12 is critical for its inhibitory function. PMID: 18160710
    21. Two mutations, nonsense and splice site, were identified in NALP12 in two families with periodic fever syndromes. PMID: 18230725
    22. Relative copy numbers for the inflammasome mRNAs for ASC, caspase-1, NALP1, and Pypaf-7 were significantly lower in patients with septic shock compared with critically ill control subjects. PMID: 18263805

    显示更多

    收起更多

  • 相关疾病：
    Familial cold autoinflammatory syndrome 2 (FCAS2)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NLRP family
  • 组织特异性：
    Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
  • 数据库链接：

    HGNC: 22938

    OMIM: 609648

    KEGG: hsa:91662

    STRING: 9606.ENSP00000319377

    UniGene: Hs.631573