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NLRC5 Antibody

  • 货号：
    CSB-PA771457LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA771457LA01HU diluted at 1:400 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA771457LA01HU diluted at 1:400 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA771457LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NLRC5 Polyclonal antibody
  • Uniprot No.：
    Q86WI3
  • 基因名：
    NLRC5
  • 别名：
    Caterpiller protein 16.1 antibody; CLR16.1 antibody; FLJ21709 antibody; FLJ39711 antibody; NLR family, CARD domain containing 5 antibody; NLR family, CARD-containing 5 antibody; NLR family, caspase recruitment domain-containing 5 antibody; NLRC5 antibody; NLRC5_HUMAN antibody; NOD-like receptor C5 antibody; NOD27 antibody; NOD4 antibody; Nucleotide-binding oligomerization domain protein 27 antibody; Nucleotide-binding oligomerization domain protein 4 antibody; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5 antibody; nucleotide-binding oligomerization domains 27 antibody; OTTHUMP00000164675 antibody; Protein Caterpiller 16.1 antibody; Protein NLRC5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein NLRC5 protein (95-208AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NLRC5 Antibody (CSB-PA771457LA01HU)，的标记方式是Non-conjugated。对于NLRC5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA771457LB01HU NLRC5 Antibody, HRP conjugated ELISA
    FITC CSB-PA771457LC01HU NLRC5 Antibody, FITC conjugated
    Biotin CSB-PA771457LD01HU NLRC5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
  • 基因功能参考文献：
    1. Genetic polymorphisms in NLRC5 may be used as prognostic markers of survival of colorectal cancer patients, as well as for survival in response to 5-FU treatment. PMID: 29762254
    2. knockdown of NLRC5 attenuates renal ischemia/reperfusion injury in vitro through the activation of PI3K/Akt signaling pathway. PMID: 29655162
    3. NLRC5 may act as a key mediator in renal fibroblast activation and fibrogenesis PMID: 29608899
    4. obtained 18 pair-wise interactions within and between the NLRC5 ad PD-L1 genes and 6 more when IFNGR variants were added PMID: 29408916
    5. Our study, for the first time, identified the possible involvement of a polymorphism within NLRC5 gene as a possible biomarker for periodontitis condition susceptibility among Italian individuals from genetic isolates. PMID: 28122660
    6. NLRC5 interacts with miR-34a.NLRC5 role in HPV16 persistence. PMID: 27423514
    7. These results demonstrate that NLRC5 promotes hepatocellular carcinoma progression via the AKT/VEGF-A signaling pathway PMID: 27338800
    8. NLRC5 not only positively correlates with the increase of beta-catenin but also coordinates the activation of downstream Wnt/beta-catenin signaling pathway, regulating cell proliferation, migration and invasion in hepatocellular carcinoma. PMID: 26975630
    9. silencing NLRC5 reduced extracellular matrix expression in keloid fibroblasts through inhibiting the TGF-beta1/Smad signaling pathway. PMID: 27525969
    10. CITA/NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and class II pathways, respectively. [review] PMID: 27087581
    11. NLRC5 expression was significantly associated with the activation of CD8(+) cytotoxic T cells and patient survival in multiple cancer types. Thus, NLRC5 constitutes a novel prognostic biomarker and potential therapeutic target of cancers. PMID: 27162338
    12. NLRC5 regulates TGFB1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis. PMID: 26592197
    13. In a transformed cell line, NLRC5 plays a significant role in IL-6 and IL-1Beta secretion. PMID: 25820389
    14. NLRC5 function is shaped by reversible ubiquitination, which modulates the NF-kappaB activation switch PMID: 26620909
    15. RSV infection of lung epithelial cells induces expression of RIG-I, NLRC5, and subsequent upregulation of HLA-A, HLA-B and HLA-C. PMID: 25972545
    16. a novel role for NLRC5 in RIG-I-mediated antiviral host responses against influenza virus infection, distinguished from the role of NLRC5 in MHC class I gene regulation. PMID: 25404059
    17. This study presents a detailed functional study of the domains of NLRC5 revealing that the N-terminal domain of human NLRC5 has intrinsic transcriptional activity. PMID: 25127861
    18. Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain. PMID: 24815518
    19. A model for full-length human NLRC5 was prepared and, besides the closed conformation of monomeric NLRC5, a heptameric platform was also modeled for the opened conformational NLRC5 monomers. PMID: 24044430
    20. rhinovirus ion channel protein 2B triggers NLRP3 and NLRC5 inflammasome activation and IL-1beta secretion in bronchial cells PMID: 23815151
    21. Expression of NLRC5 positively correlates with histocompatibility class I expression in human tissues. PMID: 22490867
    22. NLRC5 can cooperate with X1 box-binding transcription factor RFX and X2 box-binding transcription factor ATF1 in activation of histocompatibility class I promoter region. PMID: 22490869
    23. NLRC5 acts as a key transcriptional regulator of MHC I in lymphocytes and support an essential role for NLRs in directing not only innate but also adaptive immune responses. PMID: 22412192
    24. NLRC5-mediated MHC class I gene induction requires an intact nuclear localization signal and nuclear distribution of NLRC5. PMID: 22310711
    25. NLRC5 was proposed to function as a positive and as a negative regulator of IFN, NF-kappaB, AP-1 signaling and antiviral immunity. (Review) PMID: 22024701
    26. NLRC5 is a critical component of inflammasome-dependent interleukin (IL)-1beta secretion in response to a repertoire of stimuli that also activate NLRP3. PMID: 21191067
    27. function for NLRC5 in anti-viral innate immune responses PMID: 20538593
    28. NLRC5 is identified and characterized as a key regulator of proinflammatory pathways in immune cells. PMID: 20610642
    29. suggest that NLRC5 is a transcriptional regulator, orchestrating the concerted expression of critical components in the MHC class I pathway. PMID: 20639463
    30. Study identifies NLRC5 as a negative regulator that blocks two central components of the NF-kappaB and type I interferon signaling pathways and suggest an important role for NLRC5 in homeostatic control of innate immunity. PMID: 20434986
    31. NLRC5 may represent a molecular switch of interferon (IFN)-gamma activation sequence and IFN-specific response element signaling pathways contributing to antiviral defense mechanisms. PMID: 20061403

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NLRP family
  • 组织特异性：
    Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.
  • 数据库链接：

    HGNC: 29933

    OMIM: 613537

    KEGG: hsa:84166

    STRING: 9606.ENSP00000262510

    UniGene: Hs.528836