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NLGN3 Antibody

  • 货号：
    CSB-PA873703LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of U251 cells with CSB-PA873703LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NLGN3 Polyclonal antibody
  • Uniprot No.：
    Q9NZ94
  • 基因名：
    NLGN3
  • 别名：
    Gliotactin homolog antibody; HNL3 antibody; Neuroligin-3 antibody; Nlgn3 antibody; NLGN3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Neuroligin-3 protein (642-783AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NLGN3 Antibody (CSB-PA873703LA01HU)，的标记方式是Non-conjugated。对于NLGN3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA873703LB01HU NLGN3 Antibody, HRP conjugated ELISA
    FITC CSB-PA873703LC01HU NLGN3 Antibody, FITC conjugated
    Biotin CSB-PA873703LD01HU NLGN3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
  • 基因功能参考文献：
    1. Wnt/beta-catenin signaling targets the trasncription of the autism-associated Neuroligin 3 gene. PMID: 29503438
    2. NLGN3 protects retinal pigment epithelium (RPE) cells and retinal ganglion cells (RGCs) from H2O2. PMID: 29792861
    3. Our data suggest that these four previously described neuroligin mutations are not primary risk factors for autism. PMID: 28948087
    4. high-grade gliomas growth depends on microenvironmental NLGN3, identify signalling cascades downstream of NLGN3 binding in glioma, and determine a therapeutically targetable mechanism of secretion PMID: 28959975
    5. e found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses. PMID: 27805570
    6. No statistically significant haplotypes have been found associated to autism in the NLGN3 after logistic regression and permutation analysis. PMID: 27782075
    7. The synaptic protein neuroligin-3 (NLGN3) was identified as the leading candidate mitogen, and soluble NLGN3 was sufficient and necessary to promote robust high-grade glioma cell proliferation. PMID: 25913192
    8. Our data provided a further evidence for the involvement of NLGN3 and NLGN4X gene in the pathogenesis of autism in Chinese population. PMID: 24570023
    9. The present study explores, for the first time, the contribution of NLGN3 and NLGN4X genetic variants in Greek patients with autistic disorder. PMID: 23851596
    10. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population. PMID: 23468870
    11. Neuroligins are adhesion proteins that bind to beta-neurexin to form functional synapses. PMID: 23431752
    12. Data from studies using cross-linking reagents suggest that neuroligins form dimers, including homodimers and, most notably, neuroligin 1/3 heteromers; autism-associated neuroligin mutant (neuroligin 3 R471C) forms heterodimers with neuroligin 1. PMID: 22671294
    13. study provides initial evidence that a common variant in NLGN3 gene may play a role in the etiology of ASDs among affected males in Chinese Han population. PMID: 21569590
    14. further characterization of the R451C mutation in NLGN3;role in protein folding PMID: 20227402
    15. report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders PMID: 12669065
    16. No structural variants were found in the NLGN3 gene when 96 unrelated patients with autism, 24 ADHD and 24 bipolar disorder patients were analyzed. PMID: 15622415
    17. Neuroligin mutations most probably represent rare causes of autism; it is unlikely that the allelic variants in any of these genes would be major risk factors for autism. PMID: 16077734
    18. Data indicate that coding mutations in neuroligin 3 are very rarely associated to autism spectrum disorders. PMID: 16508939
    19. Splice variants of the NLGN3 gene are associated with autism. PMID: 16648374
    20. Syntrophin-gamma2 (SNTG2) is a de novo binding partner of neuroligin 3, which correlates with autism-related mutations. PMID: 17292328
    21. no evidence for an involvement of NLGN3 and NLGN4X genetic variants with autism spectrum disorder on high functioning level PMID: 18189281
    22. these data support the hypothesis that the autism-associated NL3 mutation affects information processing in neuronal networks by altering network architecture and synchrony PMID: 19406211

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  • 相关疾病：
    Autism, X-linked 1 (AUTSX1); Asperger syndrome, X-linked, 1 (ASPGX1)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 组织特异性：
    Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.
  • 数据库链接：

    HGNC: 14289

    OMIM: 300336

    KEGG: hsa:54413

    STRING: 9606.ENSP00000351591

    UniGene: Hs.438877