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NKX2-6 Antibody

  • 货号：
    CSB-PA003457
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using Nkx-2.6 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    A6NCS4
  • 基因名：
    NKX2-6
  • 别名：
    NKX2-6 antibody; NKX2F antibody; Homeobox protein Nkx-2.6 antibody; Homeobox protein NK-2 homolog F antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Nkx-2.6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development.
  • 基因功能参考文献：
    1. This study firstly links NKX2.6 loss-of-function mutation with increased susceptibility to isolated VSD. PMID: 25380965
    2. Data associated genetically defective NK2 homeobox 6 (NKX2-6) with enhanced susceptibility to atrial fibrillation (AF). PMID: 25319568
    3. Heterozygous mutations in Nkx2.6, p.V176M and p.K177X, were identified in 2 unrelated patients, one with tetralogy of Fallot and one with double outlet of right ventricle and ventricular septal defect. Increased vulnerability to TOF or DORV is discussed. PMID: 25195019
    4. NKX2-6 plays a role in human cardiogenesis. PMID: 24421281
    5. weakly activates transcription of a Cx40 promoter, may have role in heart development PMID: 15649947
    6. NKX2.5/NKX2.6 mutations are not a common cause of isolated type 1 truncus arteriosus in a small cohort of multiethnic cases. PMID: 18939937

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  • 相关疾病：
    Conotruncal heart malformations (CTHM)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NK-2 homeobox family
  • 数据库链接：

    HGNC: 32940

    OMIM: 217095

    KEGG: hsa:137814

    STRING: 9606.ENSP00000320089

    UniGene: Hs.532654