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NKX2-3 Antibody

  • 货号：
    CSB-PA848391LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate
      All lanes: NKX2-3 antibody at 3.8µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39 kDa
      Observed band size: 39 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NKX2-3 Polyclonal antibody
  • Uniprot No.：
    Q8TAU0
  • 基因名：
    NKX2-3
  • 别名：
    NKX2-3 antibody; NKX23 antibody; NKX2CHomeobox protein Nkx-2.3 antibody; Homeobox protein NK-2 homolog C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein Nkx-2.3 protein (52-148AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NKX2-3 Antibody (CSB-PA848391LA01HU)，的标记方式是Non-conjugated。对于NKX2-3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA848391LB01HU NKX2-3 Antibody, HRP conjugated ELISA
    FITC CSB-PA848391LC01HU NKX2-3 Antibody, FITC conjugated
    Biotin CSB-PA848391LD01HU NKX2-3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor.
  • 基因功能参考文献：
    1. Studies suggest oncogenic NK2 homeobox 3 homeobox protein (NKX2-3) in lymphomagenesis, and show a mouse model for studying the biology and therapy of human marginal-zone B-cell lymphomas. PMID: 27297662
    2. NKX2-3 is a key mediator for maintaining myofibroblast characteristics, and our results show that colorectal myofibroblasts, as defined by the expression of AOC3, NKX2-3, and other markers, are a distinctly different cell type from TGFbeta-activated fibroblasts PMID: 27036009
    3. The persons with a NKX2-3 G or T allele may have a moderately increased risk of CD. PMID: 24473197
    4. NKX2-3 may play different roles in ulcerative colitis and Crohn's disease pathogenesis by differential regulation of EGR1. PMID: 21968973
    5. A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both Crohn's disease and ulcerative colitis patients. PMID: 22377701
    6. The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by chromatin immunoprecipitation assay. PMID: 21803625
    7. the risk haplotype of NKX2.3 confers susceptibility to UC through increasing expression of NKX2.3 mRNA in the colonic mucosa. PMID: 21514341
    8. NKX2-3 may play an important role in inflammatory bowel disease pathogenesis by regulating endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells. PMID: 21637825
    9. Data suggest that NKX2-3 and IRGM are susceptibility loci for inflammatory bowel disease in Eastern European patients. PMID: 21049557
    10. Nkx2-3 may contribute to the pathogenesis of inflammatory bowel disease-associated colorectal cancer and sporadic colorectal cancer by regulating the Wnt signaling pathway. PMID: 20165982
    11. a decrease in Nkx2-3 gene expression level can profoundly alter the expression of genes and cellular functions relevant to the pathogenesis and progression of inflammatory bowel disease, such as EDN1. PMID: 20188614
    12. Single nucleotide polymorphism in NKX2-3 gene is associated with Crohn's disease and ulcerative colitis PMID: 18438405
    13. A positive association signal presumably common to different ethnic groups for rs10883365 was detected in the upstream region of NKX2-3. PMID: 18936107

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NK-2 homeobox family
  • 数据库链接：

    HGNC: 7836

    OMIM: 606727

    KEGG: hsa:159296

    STRING: 9606.ENSP00000342828

    UniGene: Hs.243272