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NHP2 Antibody

  • 中文名称：
    NHP2兔多克隆抗体
  • 货号：
    CSB-PA873677LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA873677LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA873677LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NHP2 Polyclonal antibody
  • Uniprot No.：
    Q9NX24
  • 基因名：
    NHP2
  • 别名：
    DKCB2 antibody; FLJ20479 antibody; H/ACA ribonucleoprotein complex subunit 2 antibody; NHP2 antibody; NHP2 like protein antibody; NHP2 ribonucleoprotein antibody; NHP2 ribonucleoprotein homolog (yeast) 1 antibody; NHP2 ribonucleoprotein homolog antibody; NHP2; S. cerevisiae; homolog of antibody; NHP2_HUMAN antibody; NHP2P antibody; NOLA2 antibody; Nucleolar protein family A member 2 (H/ACA small nucleolar RNPs) antibody; Nucleolar protein family A member 2 antibody; snoRNP protein NHP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human H/ACA ribonucleoprotein complex subunit 2 protein (1-153AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NHP2 Antibody (CSB-PA873677LA01HU)，的标记方式是Non-conjugated。对于NHP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA873677LB01HU NHP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA873677LC01HU NHP2 Antibody, FITC conjugated
    Biotin CSB-PA873677LD01HU NHP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
  • 基因功能参考文献：
    1. In this work, we have uncovered a putative role of epigenetic regulation in a subset of human snoRNP complexes that are involved in the site-specific modification of RNA. We find that a subset of box C/D snoRNAs are methylated at the 1n position and that this blocks both 15.5k binding and the formation of the kinked conformation in vivo. PMID: 28623187
    2. Indian aplastic anemia patients did not have NHP2 mutations. PMID: 25906515
    3. Effects of dyskeratosis congenita mutations in NHP2 on assembly of H/ACA pre-RNPs PMID: 20008900
    4. NOLA2 expression in patients with squamous cell lung cancer increased by 70% which makes it a highly informative marker of squamous cell lung cancer PMID: 15889794
    5. The analysis of two other proteins, NHP2 and GAR1, that together with dyskerin and NOP10 are key components of telomerase and small nucleolar ribonucleoprotein (snoRNP) complexes, is described. PMID: 18523010

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  • 相关疾病：
    Dyskeratosis congenita, autosomal recessive, 2 (DKCB2)
  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
  • 蛋白家族：
    Eukaryotic ribosomal protein eL8 family
  • 组织特异性：
    Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.
  • 数据库链接：

    HGNC: 14377

    OMIM: 606470

    KEGG: hsa:55651

    STRING: 9606.ENSP00000274606

    UniGene: Hs.744074