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NFIC Antibody

  • 货号：
    CSB-PA015756LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA015756LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA015756LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NFIC Polyclonal antibody
  • Uniprot No.：
    P08651
  • 基因名：
    NFIC
  • 别名：
    1110019L22Rik antibody; 1500041O16Rik antibody; AA589446 antibody; AI746521 antibody; CAAT box transcription factor antibody; CCAAT binding transcription factor antibody; CCAAT box binding transcription factor antibody; CCAAT-box-binding transcription factor antibody; CNFI C antibody; CTF antibody; CTF5 antibody; MGC137374 antibody; MGC20153 antibody; NF I antibody; NF I/C antibody; NF-I/C antibody; NF1 C antibody; NF1-C antibody; NF1C antibody; NFI antibody; NFI-C antibody; NFI/C antibody; NFIC antibody; NFIC_HUMAN antibody; Nuclear factor 1 antibody; Nuclear factor 1 C type antibody; Nuclear factor 1 C-type antibody; Nuclear factor 1/C antibody; Nuclear factor I/C (CCAAT binding transcription factor) antibody; Nuclear factor I/C antibody; TGGCA binding protein antibody; TGGCA-binding protein antibody; Transcription factor NFIC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nuclear factor 1 C-type protein (201-428AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NFIC Antibody (CSB-PA015756LA01HU)，的标记方式是Non-conjugated。对于NFIC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015756LB01HU NFIC Antibody, HRP conjugated ELISA
    FITC CSB-PA015756LC01HU NFIC Antibody, FITC conjugated
    Biotin CSB-PA015756LD01HU NFIC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
  • 基因功能参考文献：
    1. Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for the interaction of the (apolipoprotein E) APOE epsilon4 allele with NFIC SNP. PMID: 28183528
    2. Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer PMID: 25879941
    3. Results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs. PMID: 24801901
    4. Over-expression of NFIC increased cell proliferation, mineralization nodule formation and alkaline phosphatase activity in stem cells from the apical papilla. PMID: 25668322
    5. transcription factor Nuclear Factor 1-C (NF1C) as a candidate to regulate AHR transcription in a polymorphism-dependent manner PMID: 23208493
    6. These data suggest a critical role for calcineurin in NFI transcriptional regulation and in the determination of malignant glioma infiltrative properties. PMID: 23839947
    7. the influence of i3T3 on the expression and DNA binding of NFI, another TF important for cell proliferation and cell cycle progression PMID: 22420942
    8. novel role of NF1-C2 in tumor development and epithelial-to-mesenchymal transition in breast cancer; NF1-C2 is lost during tumor progression and virtully absent from lymph node metastases; FoxF1 was was found to be a direct repressed target of NF1-C2 PMID: 20145151
    9. A specific region (-688 to -611 bp) was discovered in the IRS2 promoter essential for basal promoter activity and oxidative stress induced transcription depending on ERK activation and SP1 and NFI binding in human hepatocytes. PMID: 19755487
    10. diminished NF-1C-dependent repression may be one mechanism underlying increased basal CYP17 promoter activity and altered gene expression in PCOS (polycystic ovary syndrome) theca cells. PMID: 14684846
    11. The BAF complex & NF1/CTF might act as components of the RNAP II holoenzyme to participate in formation of transcriptional pre-initiation complex. PMID: 15999204
    12. Data demonstrate that nuclear Jak2 regulates the amount of active NF1-C2 through tyrosine phosphorylation and proteasomal degradation. PMID: 16847321
    13. the chromatin architecture of the promoters does not permit strong association of GR in the absence of NF1 PMID: 17186943
    14. we suggest that bHLH factors recruit NFI to enhance skeletal muscle Na(+) channel expression. PMID: 17936922
    15. All NFI isoforms were found to be expressed in human corneal epithelial cells grown on laminin. PMID: 18421093
    16. These are the first studies to analyze the expression of NFI-C isoforms in dental versus nondental cells/tissues. PMID: 18765927
    17. These results suggest that alpha5 gene expression is likely dictated by subtle alterations in the nuclear ratio of TFs that either repress (NFI) or activate (Sp1 and AP-1) alpha5 transcription in corneal epithelial cells. PMID: 18775869
    18. These results imply a central role of NFI-C in the interplay of the two signaling pathways and in regulation of the progression of tissue regeneration. PMID: 19752192

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CTF/NF-I family
  • 数据库链接：

    HGNC: 7786

    OMIM: 600729

    KEGG: hsa:4782

    STRING: 9606.ENSP00000465655

    UniGene: Hs.170131