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NFIA Antibody

  • 货号：
    CSB-PA619635ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: NFIA antibody at 2.35μg/ml
      Lane 1: Rat heart tissue
      Lane 2: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 55, 61 kDa
      Observed band size: 56 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NFIA Polyclonal antibody
  • Uniprot No.：
    Q12857
  • 基因名：
    NFIA
  • 别名：
    1110047K16Rik antibody; 9430022M17Rik antibody; CCAAT Box Binding Transcription Factor antibody; CCAAT-box-binding transcription factor antibody; CTF antibody; FLJ39164 antibody; NF I/A antibody; NF-I/A antibody; NF1-A antibody; NFI A antibody; NFI L antibody; NFI-A antibody; NFIA antibody; NFIA_HUMAN antibody; Nuclear factor 1 A type antibody; Nuclear factor 1 A-type antibody; Nuclear factor 1/A antibody; Nuclear factor I/A antibody; TGGCA binding protein antibody; TGGCA-binding protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Nuclear factor 1 A-type protein (180-330AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
  • 基因功能参考文献：
    1. The consistent overlap in clinical presentation provides further evidence of the critical role of NFIA haploinsufficiency in the development of the 1p32-p31 microdeletion syndrome phenotype. PMID: 28941020
    2. Data define a previously unknown nuclear factor I-A-nuclear factor-kappaB feed-forward regulation that may contribute to glioblastoma cell survival. PMID: 27994064
    3. Studies indicate the role of nuclear factor one (NFIs) as epigenetic regulators in cancer. PMID: 28076901
    4. Altogether, these results demonstrated that miR-370 suppressed hepatitis B virus gene expression and replication through repressing NFIA expression, which stimulates hepatitis B virus replication via direct regulation on hepatitis B virus Enhancer I activities. PMID: 27664977
    5. We verified that NFIA binds to the IGFBP2 promoter and transcriptionally enhances IGFBP2 expression levels. We identified that NFIA-mediated IGFBP2 signaling pathways are involved in miR-302b-induced glioma cell death. PMID: 28323865
    6. miR-191 was upregulated in patients with middle- and late-stage NSCLC, and in NSCLC cell lines, under mild hypoxic conditions. miR-191 promoted the proliferation and migration of NSCLC under chronic hypoxic conditions, and this promotion may be associated with its targeting of NFIA. PMID: 28075452
    7. Dihydrocapsaicin can significantly decrease proinflammatory cytokines through enhancing NFIA and inhibiting NF-kappaB expression PMID: 27267730
    8. These results demonstrated that RP5833A20.1 inhibited tumor cell proliferation, induced apoptosis and inhibited cellcycle progression by suppressing the expression of NFIA in U251 cells. PMID: 27779670
    9. NFI-A is involved in the miR-21-induced expression of IL-10 in B cells in nasopharyngeal carcinoma; Il-10 is capable of suppressing CD8+ T-cell activities. PMID: 25544502
    10. microRNA-136 targeted and degraded NFIA, which induced the release of microRNA-223, promoting CD11b expression. Direct base pairing occurs between miR-136 and the 3' UTR of NFIA mRNA. PMID: 26329426
    11. this family also carried a microdeletion affecting solely the NFIA gene, this study substantiates the importance of this gene in craniofacial development. PMID: 25714559
    12. TGF-beta-mediated suppression of ANT2 through NF1/Smad4 complexes contributes to oxidative stress and DNA damage during induction of cellular senescence. PMID: 25220407
    13. a strong candidate gene for asthma and allergic rhinitis PMID: 24560411
    14. RP5-833A20.1/miR-382-5p/NFIA pathway was essential to the regulation of cholesterol homeostasis and inflammatory reactions. PMID: 25265644
    15. This report presents the first case of an intragenic deletion within the NFIA gene that is still consistent with classic clinical phenotypes present in previously reported cases of chromosome 1p31.3 related deletion. PMID: 24462883
    16. High nuclear factor IA expression is associated with glioblastomas. PMID: 24305710
    17. These studies represent the first characterization of miR-223/NFIA axis function in glioma PMID: 23946414
    18. These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder. PMID: 22925353
    19. NFIA expression in white matter lesions of human newborns with neonatal HIE, as well active MS lesions in adults, revealed that it is similarly expressed in oligodendrocyte progenitors and not oligodendrocytes. PMID: 22807310
    20. Role in the expression mechanism of hNaPi-IIb gene transcription. PMID: 15458926
    21. nuclear factor I has a role in the intrinsic control of cerebellar granule neuron gene expression PMID: 15466411
    22. Distribution of nuclear factor I binding sites correlate with Z-DNA forming regions in human chromosome 22. PMID: 15598822
    23. Data show that human granulocytic differentiation is controlled by a regulatory circuitry involving miR-223 and two transcriptional factors, NFI-A and C/EBPalpha. PMID: 16325577
    24. The NF1-A transcription factor plays an important role in the transcriptional activation of the TR2 orphan receptor gene expression via a promoter activating cis-element. PMID: 17010934
    25. The mouse Nfia mutant phenotype and the common features among five human cases indicate that NFIA haploinsufficiency contributes to a novel human central nervous system malformation syndrome that can also include ureteral and renal defects. PMID: 17530927
    26. NFI family of transcription factors plays a key role in the regulation of both the B-FABP and GFAP genes in malignant glioma cells. PMID: 19540848
    27. in early hematopoiesis, the NFI-A expression level acts as a novel factor channeling HPCs into either the E or G lineage PMID: 19542302
    28. Disruption of the Nfia gene in the mouse causes perinatal lethality, agenesis of the corpus callosum and hydrocephalus. PMID: 10518556

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  • 相关疾病：
    Brain malformations with or without urinary tract defects (BRMUTD)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CTF/NF-I family
  • 数据库链接：

    HGNC: 7784

    OMIM: 600727

    KEGG: hsa:4774

    STRING: 9606.ENSP00000360231

    UniGene: Hs.740757