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NFATC2 Antibody

  • 货号：
    CSB-PA418194
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Human-colon, antibody was diluted at 1:100
  • 其他：

产品详情

  • Uniprot No.：
    Q13469
  • 基因名：
  • 别名：
    AI607462 antibody; cytoplasmic 2 antibody; KIAA0611 antibody; NF ATc2 antibody; NF ATp antibody; NF-ATc2 antibody; NF-ATp antibody; NFAC2_HUMAN antibody; NFAT 1 antibody; NFAT pre existing subunit antibody; NFAT pre-existing subunit antibody; NFAT transcription complex, preexisting component antibody; NFAT1 antibody; NFAT1-D antibody; NFATc2 antibody; NFATp antibody; Nuclear factor of activated T cells cytoplasmic 2 antibody; Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2 antibody; Nuclear factor of activated T cells pre-existing component antibody; Nuclear factor of activated T cells, preexisting component antibody; Nuclear factor of activated T-cells antibody; Preexisting nuclear factor of activated T cells 2 antibody; T cell transcription factor NFAT 1 antibody; T-cell transcription factor NFAT1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 640-700
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.
  • 基因功能参考文献：
    1. The data indicate that expression of CRTh2 is regulated through the competitive action of GATA3 and NFAT1. PMID: 29969451
    2. NFAT1-regulated IL6 signalling contributes to aggressive phenotypes of glioma PMID: 29258522
    3. Results show that NFAT1 expression is regulated by ASIC2 under acidosis and that NFAT1, binds to genes clustered in pathways involved in Rho GTPase signaling and calcium signaling. PMID: 28927426
    4. Our results indicate that NFATc2 may be used as an early diagnostic or predictive biomarker for colorectal carcinoma as well as a therapeutic target PMID: 28504924
    5. NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ ALDH1A1 axis in lung adenocarcinoma. PMID: 28737489
    6. NFATc2 and Sp1 are co-localized in cell nuclei and physically interact at the NFAT target sequence termed NFAT-responsive promotor construct. Sp1 increases the functional activity of its binding partner NFATc2. PMID: 28774282
    7. Our data have shown for the first time the regulation of CacyBP/SIP gene expression by NFAT1. Since NFAT transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP in the immune system. PMID: 28526484
    8. An interaction of NFAT1 and the beta-catenin pathway, validate lysophosphatidic acid as an in vivo activator of beta-catenin-dependent transcription during allograft fibrogenesis. PMID: 28240604
    9. the expression of NFATc2 promotes melanoma dedifferentiation and immune escape PMID: 26387540
    10. NFAT1 is stimulated by subplasmalemmal Ca2+ microdomains, whereas NFAT4 additionally requires Ca2+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors. PMID: 27863227
    11. NFAT1 overexpression is associated with Melanoma Tumor Growth and Metastasis. PMID: 27013197
    12. These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies. PMID: 27399331
    13. NFAT1 silencing could suppress cell migration and invasion through MMP-3. PMID: 28024290
    14. FOXP1 has protein-protein interaction with NFAT1 on DNA and enhances breast cancer cell migration by repressing NFAT1 transcriptional activity. PMID: 27859969
    15. we describe a novel mechanism by which GSK-3beta fine-tunes NFATc2 and STAT3 transcriptional networks to integrate upstream signaling events that govern pancreatic cancer progression and growth. PMID: 26823495
    16. Up-regulation of Store-operated Ca2+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells. PMID: 26903518
    17. two NFAT isoforms (NFAT4 and NFAT1) have shifted band-pass windows for the same receptor in the GPCR signaling pathway PMID: 26374065
    18. These data suggest that NFATc2 expression is regulated by intracellular calcium and in vitro stretch, and that the stretch response in human myometrial cells is dependent upon intracellular calcium signalling pathways. PMID: 26238508
    19. inhibits CCR7 expression during the course of dendritic cell maturation PMID: 25797200
    20. NFAT1-mediated IL8 production promotes the migration of primary human neutrophils in vitro and also promotes neutrophil infiltration in tumor xenografts PMID: 25735562
    21. In multivariate logistic regression, the intronic rs6021191 variant in nuclear factor of activated T cells 2 (NFATC2) had the strongest association with hypersensitivity to asparaginase. PMID: 25987655
    22. Results show that two protein isoforms NFAT1 and NFAT4 are both cytosolic and stimulated by the same Ca2+ messenger but require distinct subcellular Ca2+ signals for activity. PMID: 25818645
    23. no significant correlation of genetic polymorphisms with disease activity in rheumatoid arthritis patients in Poland PMID: 25376468
    24. NFAT-1, STAT-1 and AP-1 might be the central transcription factors in the pathogenesis of pre-eclampsia. PMID: 24931237
    25. Data suggest involvement of SALL4 (sal-like 4) and NFATC2(nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 ) genes disruption in cardiac and skeletal anomalies. PMID: 24486774
    26. NFATc2 exhibited a higher relative affinity for binding site DS3 as compared with members of the C/EBP family (C/EBP alpha and beta). PMID: 24551078
    27. NFAT1 is differentially expressed in stimulated CD4-positive vs CD8-positive T cells. PMID: 24173147
    28. Translocation of NFAT1 to the cell nucleus is a direct, sensitive, reproducible and quantitative pharmacodynamic readout for tacrolimus action. PMID: 24136923
    29. USP22 deubiquitinates and stabilizes NFATc2 protein levels thereby promoting IL2 expression. PMID: 24561192
    30. Using a human CTL system model based on a CD8(+)/CD103(-) T cell clone specific of a lung tumor-associated Ag, we demonstrated that the transcription factors Smad2/3 and NFAT-1 are two critical regulators of this process. PMID: 24477908
    31. in vivo biochemical or genetic inhibition of NFATc2 activity in megakaryocyte diminishes platelet CD40L implicates the NFATc2/EGR-1 axis as a key regulatory pathway of inflammatory and immunomodulatory activity in platelets PMID: 24106272
    32. Overexpressed NFAT1 in glioblastoma multiforme cells was mainly located in the nucleus, where it acted as a transcription factor. PMID: 23762456
    33. Both WNT5A and NFATc2 proteins are highly expressed in human pancreatic cancer tissues. PMID: 23359789
    34. Data suggest a model in which IL-2 transcriptional synergy is mediated by the unique recruitment of a cJun homodimer to the -45 NFAT site by NFATc2, where it acts as a co-activator for IL-2 transcription. PMID: 23665382
    35. haplo-insufficiency of NFATC2 cooperates with activation of the JAK-STAT signaling pathway in the pathogenesis of JAK2V617F-positive ET with del(20q). PMID: 22911897
    36. Transfection with HCV C gene up-regulates NFAT1 expression and promotes the cell cycle progression and proliferation of intrahepatic cholangiocarcinoma cells. PMID: 22699055
    37. LCN2 and TWEAKR-TWEAK as crucial downstream effectors of NFAT1 that regulate breast cancer cell motility and invasive capacity. PMID: 22767506
    38. Data elucidate a previously unidentified mechanism by which galectin-3 regulates autotaxin and assign a novel role for NFAT1 during melanoma progression. PMID: 22986745
    39. Endorepellin affects angiogenesis by antagonizing diverse VEGFR2-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1alpha and VEGFA and concurrent inhibition of NFAT1 activation. PMID: 23060442
    40. NFAT1 directly binds to distal sites in the c-Myc promoter with different affinities. PMID: 22333584
    41. Here we show that the calcineurin/nuclear factor of activated T cells c2 (NFATc2) pathway has an antiapoptotic role in melanoma cells. PMID: 22718120
    42. Transcription factor NFAT1 activates the mdm2 oncogene independent of p53. PMID: 22787160
    43. The present study investigated the effect of heart failure aetiology on Ca(+2) handling proteins and NFAT1, MEF2C and GATA4 (transcription factors) in the same cardiac tissue. PMID: 22363514
    44. Inhibition of NFAT or targeting of NFATc3 with small interfering RNA (siRNA) lowers the AIF-1/IRT-1 ratio and favours an anti-proliferative outcome for atherosclerosis. PMID: 22116621
    45. calcium responsiveness of IL-31 promoter required NFAT binding sites that bind NFATc1 and NFATc2 in vitro and in vivo. PMID: 22045870
    46. a novel negative cross talk between the NFAT1- and Stat5-signaling cascades that may affect breast tumor formation, growth, and metastasis PMID: 21964595
    47. The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by chromatin immunoprecipitation assay. PMID: 21803625
    48. the prolonged IL-4 expression in NFAT1 deficient Th2 cells is mediated by preferential binding of JUNB/SATB1 to the IL-4 promoter with permissive chromatin architecture PMID: 21799768
    49. a critical role of the GSK-3beta-HDM2 signaling loop in the regulation of NFATc2 protein stability and growth promotion PMID: 21628454
    50. Data demonstrate that IRF-2BP2 is a negative regulator of the NFAT1 transcription factor and suggest that NFAT1 repression occurs at the transcriptional level. PMID: 21576369

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
  • 组织特异性：
    Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trac
  • 数据库链接：

    HGNC: 7776

    OMIM: 600490

    KEGG: hsa:4773

    STRING: 9606.ENSP00000379330

    UniGene: Hs.744148