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NEUROD2 Antibody

  • 货号：
    CSB-PA003412
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using Neuro D2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q15784
  • 基因名：
    NEUROD2
  • 别名：
    bHLHa1 antibody; class A basic helix loop helix protein 1 antibody; Class A basic helix-loop-helix protein 1 antibody; NDF2_HUMAN antibody; NDR2 antibody; NDRF antibody; neuroD related factor antibody; NeuroD-related factor antibody; NeuroD2 antibody; neurogenic basic helix loop helix protein antibody; neurogenic differentiation 2 antibody; Neurogenic differentiation factor 2 antibody; neuronal differentiation 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Neuro D2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter.
  • 基因功能参考文献：
    1. Our findings suggest that the NEUROD2 gene could play a role in the pathophysiology of neurocognitive dysfunctions as well as in the change of cognitive symptoms under antipsychotic treatment in schizophrenia and schizoaffective disorder. PMID: 28470106
    2. Downregulation of NEUROD2 is associated with neurodevelopmental defects in trisomies 18. PMID: 22752091
    3. The results of this study did not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence. PMID: 20880594
    4. Lower neuroD2 mRNA levels was found in opiate-dependent individuals in the cortex and hippocampus. PMID: 16607387
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 7763

    OMIM: 601725

    KEGG: hsa:4761

    STRING: 9606.ENSP00000306754

    UniGene: Hs.322431