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NETO2 Antibody

  • 货号：
    CSB-PA015716GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8NC67
  • 基因名：
    NETO2
  • 别名：
    Brain specific transmembrane protein antibody; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 2 antibody; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2 antibody; BTCL2 antibody; FLJ10430 antibody; FLJ14724 antibody; FLJ90456 antibody; NEOT2 antibody; NETO 2 antibody; Neto2 antibody; NETO2_HUMAN antibody; Neuropilin (NRP) and tolloid (TLL) like 2 antibody; Neuropilin and tolloid like protein 2 antibody; Neuropilin and tolloid-like protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NETO2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission.
  • 基因功能参考文献：
    1. upregulation of NETO2 gene is first stipulated by the isoform 1 (NM_018092.4), and the probable mechanism of its activation is associated with the increased expression of SAP30 transcription factor. PMID: 29989576
    2. NETO2 may be involved in colorectal cancer progression, but is not directly associated with epithelial-mesenchymal transition PMID: 29297384
    3. Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors PMID: 26277340
    4. NETO2 upregulation could serve as a potential biomarker for the prediction of advanced tumor progression and unfavorable prognosis in patients with colorectal carcinoma. PMID: 26699544
    5. Determination of the neuropilin and tolloid-like protein 2 signal peptide cleavage site by N-terminal sequencing. PMID: 15340161
    6. Rat neto2 plays a role in glutamate signaling in the brain by modulating the function of kainate receptors. PMID: 19217376

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 数据库链接：

    HGNC: 14644

    OMIM: 607974

    KEGG: hsa:81831

    STRING: 9606.ENSP00000455169

    UniGene: Hs.645802