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NEO1 Antibody

  • 中文名称：
    NEO1兔多克隆抗体
  • 货号：
    CSB-PA015712GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q92859
  • 基因名：
    NEO1
  • 别名：
    Immunoglobulin superfamily DCC subclass member 2 antibody; NEO1 antibody; NEO1_HUMAN antibody; Neogenin antibody; Ngn (gene name) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NEO1-Specific
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
  • 基因功能参考文献：
    1. Overexpression of Neo1 significantly reduced the GC cell sensitivity to cisplatin and increased the cell viability, motility and adhesion ability, and while silencing of Neo1 showed contrary results. PMID: 30064133
    2. Endogenous NTN4/NEO1 maintain neuroblastoma growth via both pro-survival and pro-migratory molecular signaling. PMID: 28038459
    3. Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin. PMID: 27716118
    4. these results suggested that GD3 recruits gamma-secretase to lipid/rafts, allowing efficient cleavage of neogenin. PMID: 27288875
    5. The hemizygous 15q deletion unmasks the recessive functional polymorphism in NEO1 which plays a pivotal role in cortical interneuron development; study provides the first evidence linking NEO1 with autism spectrum disorders in humans PMID: 26518331
    6. Neogenin influences both cadherin dynamics and junctional tension. PMID: 27029596
    7. Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways PMID: 25909166
    8. The present study demonstrates that neogenin may be a tumor suppressor in breast cancer. Neogenin may serve as a potential diagnostic marker and therapeutic target for breast cancer. PMID: 25998984
    9. These results show how repulsive guidance molecule acts as the central hub that links BMP2 and NEO1 and physically connects these fundamental signaling pathways. PMID: 25938661
    10. Neogenin expression is inversely associated with breast cancer grade. PMID: 25416629
    11. high-expression of neogenin-1 promotes gastric cancer proliferation and motility PMID: 24930499
    12. miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin. PMID: 24657544
    13. these results highlight Neogenin1 as a novel downstream effector of the Sonic Hedgehog pathway in medulloblastoma PMID: 23775842
    14. two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner. PMID: 23744777
    15. neogenin forms a ternary complex with both MT2 and HJV at the plasma membrane. The complex facilitates HJV cleavage by MT2, and release of the cleaved HJV from the cell occurs after a retrograde trafficking through the TGN/Golgi compartments. PMID: 22893705
    16. pattern of distribution suggests that a functional netrin-4-neogenin pathway might be restricted to syncytiotrophoblasts, mesenchymal cells, and villous endothelial cells PMID: 22705235
    17. the proposed role of neogenin as a tumor suppressor in gliomas PMID: 22666451
    18. identification of neogenin-binding site on the repulsive guidance molecule A PMID: 22396795
    19. Netrin-1 can promote the potential of proliferation and invasion of extravillous trophoblasts in vitro through its receptors neogenin and UNC5B. PMID: 19570425
    20. Neogenin FN5, which does not bind hemojuvelin in isolation, exhibits a highly electropositive surface, which may be involved in interactions with negatively-charged polysaccharides or phospholipids in the membrane bilayer. PMID: 20971194
    21. neogenin negatively regulates the functions of BMP and that this effect of neogenin is mediated by the activation of RhoA. PMID: 21149453
    22. results show that different isoforms of hemojuvelin may play unique physiological roles through defined interactions with distinct signaling proteins such as BMP2 and neogenin, and demonstrate that some of these interactions are defective. PMID: 18287331
    23. This study supports the hypothesis that, as in the embryo, neogenin regulates fundamental signalling pathways important for neurogenesis in the adult mouse and human forebrain. PMID: 20575069
    24. neogenin and restin have roles in proproliferation/survival action on ovarian cancer cells PMID: 12833147
    25. neogenin may play a role in mammary carcinogenesis as well as morphogenesis PMID: 16324219
    26. HJV-induced BMP signaling and hepcidin expression are not altered by neogenin overexpression or by inhibition of endogenous neogenin expr PMID: 18326817
    27. the neogenin intracellular domain regulates gene transcription via nuclear translocation PMID: 18391016
    28. neogenin-mediated HJV release occurs after the HJV-neogenin complex is internalized from the cell surface PMID: 18445598
    29. Results show that the serine/threonine kinase death-associated protein kinase (DAPK) is involved in the signal transduction of neogenin. PMID: 18583991
    30. Results support that hepatic neogenin possesses two functions, mediation of cellular HJV release, and stimulation of HJV-enhanced hepcidin expression. PMID: 19564337

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, DCC family
  • 组织特异性：
    Widely expressed and also in cancer cell lines.
  • 数据库链接：

    HGNC: 7754

    OMIM: 601907

    KEGG: hsa:4756

    STRING: 9606.ENSP00000261908

    UniGene: Hs.388613