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NENF Antibody

  • 货号：
    CSB-PA892354NA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA892354NA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA892354NA01HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NENF Polyclonal antibody
  • Uniprot No.：
    Q9UMX5
  • 基因名：
    NENF
  • 别名：
    Cell growth inhibiting protein 47 antibody; Cell immortalization-related protein 2 antibody; CIR2 antibody; Nenf antibody; NENF_HUMAN antibody; Neudesin antibody; Neuron derived neurotrophic factor antibody; Neuron-derived neurotrophic factor antibody; SCIRP10 antibody; SCIRP10 related protein antibody; Secreted protein of unknown function antibody; Spinal cord injury related protein 10 antibody; SPUF antibody; SPUF protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Neudesin protein (149-167AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NENF Antibody (CSB-PA892354NA01HU)，的标记方式是Non-conjugated。对于NENF Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892354NB01HU NENF Antibody, HRP conjugated ELISA
    FITC CSB-PA892354NC01HU NENF Antibody, FITC conjugated
    Biotin CSB-PA892354ND01HU NENF Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance.
  • 基因功能参考文献：
    1. High NENF expression is associated with liver cancer. PMID: 24763612
    2. Human neudesin of 172 amino acids with high similarity ( approximately 91% identity) to mouse neudesin was identified; the human neudesin gene was mapped to chromosome 1p33. PMID: 15605373
    3. Describes the predicted heme-binding domains in the human neudesin protein sequence. PMID: 18056703
  • 亚细胞定位：
    Secreted, extracellular space. Mitochondrion. Endoplasmic reticulum.
  • 蛋白家族：
    Cytochrome b5 family, MAPR subfamily
  • 组织特异性：
    Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.
  • 数据库链接：

    HGNC: 30384

    OMIM: 611874

    KEGG: hsa:29937

    STRING: 9606.ENSP00000355955

    UniGene: Hs.461787