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NEK8 Antibody

  • 货号：
    CSB-PA964484
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA964484(NEK8 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q86SG6
  • 基因名：
    NEK8
  • 别名：
    JCK antibody; NEK 8 antibody; NEK12A antibody; NEK8 antibody; NEK8_HUMAN antibody; Nephrocystin 9 antibody; Never in mitosis A-related kinase 8 antibody; NIMA (never in mitosis gene a) related kinase 8 antibody; NIMA related kinase 8 antibody; NIMA-family kinase NEK8 antibody; NIMA-related kinase 12a antibody; Nima-related protein kinase 12a antibody; NimA-related protein kinase 8 antibody; NPHP9 antibody; Serine/threonine-protein kinase Nek8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human NEK8
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
  • 基因功能参考文献：
    1. NEK8 plays a critical role in replication fork stability through its regulation of the DNA repair and replication fork protection protein RAD51. PMID: 27892797
    2. The mutations: c.2069_2070insC variant (p.Ter693LeufsTer86), and a c.1043C>T variant (p.Thr348Met) in RCC1 domain of NEK8 in two brothers with cardiac, renal, and hepatic anomalies PMID: 26697755
    3. our study demonstrates that NEK8 human mutations cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway PMID: 26967905
    4. NEK8 may be a new target gene of HIFs; pVHL can down-regulate NEK8 via HIFs to maintain the primary cilia structure in human renal cancer cells PMID: 25451921
    5. NEK8 is essential for organ development and that the complete loss of NEK8 perturbs multiple signalling pathways resulting in a severe early embryonic phenotype. PMID: 23418306
    6. Mutation in NEK8 is associated with renal ciliopathies PMID: 23973373
    7. ANKS6 as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8, INVS and NPHP3. PMID: 23793029
    8. NPHP9 promotes signalling through the transcriptional co-activator TAZ. PMID: 23026745
    9. study finds that induction of ciliogenesis upon cell cycle exit is accompanied by both activation and proteasomal degradation of Nek8, and that activation is dependent upon phosphorylation within the catalytic domain PMID: 22106379
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 21068128
    11. Data demonstrate for the first time that Nek8 is a novel tumor associated gene, and shares considerable sequence homology with the Nek family of protein kinases and may be involved in G(2)/M progression. PMID: 15019993
    12. mutations cause nephronophthisis; mutant forms show defects in ciliary localization PMID: 18199800
    13. characterization of the proteome in mice that have a double point mutation in the related gene. PMID: 15872312

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  • 相关疾病：
    Nephronophthisis 9 (NPHP9); Renal-hepatic-pancreatic dysplasia 2 (RHPD2)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 组织特异性：
    Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.
  • 数据库链接：

    HGNC: 13387

    OMIM: 609799

    KEGG: hsa:284086

    STRING: 9606.ENSP00000268766

    UniGene: Hs.448468